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Seth Baum

Seth Baum

Researcher

Sep 16, 2026

5:18
And so people understand that this is just one type of approach for lowering LPA and that there are a lot of other approaches out there that we're looking at.
5:27
Yeah.
5:29
So pellocarsin is an antisense oligonucleotide.
5:33
It's delivered on a monthly basis.
5:36
It impacts basically the creation, translation, creation of the protein ApoA.
5:43
ApoA is a a tail on LpA, and by doing this, it decreases LpA levels.
5:50
I should mention, I think, what LpA is.

8 MINS LATER

13:55
So maybe expand on that a little bit more.
24:24
So tell us about what the guidelines say about lipoprotein A.
24:27
So I'm happy to hear you say that a lot of cardiologists are measuring that because that to me means you've spoken to a lot of people who are measuring it.
24:35
The reality is that in the United States, only about 5% of the population has had LpA studied, checked.
24:42
So we've definitely under-checked.
24:45
And so what is LpA? LpA, or lipoprotein small a, is like a very small LDL particle with a little tail on it called ApoA.
24:54
And it is a triple threat.
24:56
It increases the risk of the development of atherosclerosis.
28:04
okay so
7:42
A- are you just bummed out all the time?
7:44
No.
7:46
Occasionally, but most of the time, no.
7:49
And part of it is just because at a certain point, it, it just becomes a job, right? On, on a day-to-day basis, my focus is not on the emotional gravity of what I'm doing, it's on the, darn it, I have like 30 emails that I need to reply to, and I have this deadline coming up, and I have this deadline that passed last week and I still haven't done it, and they're mad at me, and, you know, things like that.
8:14
The other half of it is that there is a bright side to this, because if we manage to avoid the collapse of this civilization that we have, the future's looking good.
8:28
The future is full of potential for us.
12:49
Tell me why.
12:50
Imagine the war in Ukraine playing out in a way that is difficult for not just Russia per se, but the Putin regime in particular.

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