
Senolytic
Class of drugsWikipedia
4
MENTIONS
3
EPISODES
3
PODCASTS
Search complete. 4 mentions across 3 episodes found for "Senolytic".
Sep 15, 2026
#473: Why Most "Regenerative" Therapies Fail | Revolutionary Immune Hacks and Stem Cell Breakthroughs With Dr. Rafael Gonzalez
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82:33Nathalie NiddamHOST
Beautiful.
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82:34Nathalie NiddamHOST
Senolytics.
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82:37Rafael GonzalezGUEST
Uh, hype.
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82:39Rafael GonzalezGUEST
And the reason why hype-
The Peptide Secrets to a Youthful Face : 1536
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20:33Dave AspreyHOST
How do you get rid of senescent cells in your skin?
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20:36Carolina Reis de OliveiraGUEST
So in our case, our peptide, it works not as a senolytic molecule in a way that would kill the senescent cells itself.
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20:46Dave AspreyHOST
Mm.
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20:46Carolina Reis de OliveiraGUEST
It works as, uh, what we call senomorphic, basically in two ways.
9 MINS LATER
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29:25Carolina Reis de OliveiraGUEST
And when we measured the biological age when we treated skins with OS1, we saw a reduction in 2.5 years in the biological age of the skin.
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29:37Dave AspreyHOST
Wow.
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29:37Carolina Reis de OliveiraGUEST
And we compared with rapamycin, which, you know, it's a very known, like, senolytic, and rapamycin was not able to reduce the biological age in a significant way.
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29:47Carolina Reis de OliveiraGUEST
So it was very interesting to see that by reducing senescent cells, we reduce inflammation, we reduce markers like IL 6, IL 8.
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Unknown podcast
The Most Relaxing Facts About Aging to Fall Asleep To
Aug 30 · 1 Mention
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166:47speaker_4NARRATOR
They can release inflammatory signals and enzymes that disrupt tissue structure, which may contribute to frailty and age-related disease.
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166:56speaker_4NARRATOR
Senolytics are drugs designed to selectively remove these cells, like pruning overgrown branches so a tree can thrive.
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167:04speaker_4NARRATOR
In animal studies, clearing senescent cells has improved aspects of function in some contexts, which is why the field is so exciting.
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167:13speaker_4NARRATOR
Human research is newer.