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Senolytic

Senolytic

Class of drugsWikipedia

Search complete. 4 mentions across 3 episodes found for "Senolytic".

Sep 15, 2026

Dave AspreyHOST
20:33
How do you get rid of senescent cells in your skin?
Carolina Reis de OliveiraGUEST
20:36
So in our case, our peptide, it works not as a senolytic molecule in a way that would kill the senescent cells itself.
Dave AspreyHOST
20:46
Mm.
Carolina Reis de OliveiraGUEST
20:46
It works as, uh, what we call senomorphic, basically in two ways.

9 MINS LATER

Carolina Reis de OliveiraGUEST
29:25
And when we measured the biological age when we treated skins with OS1, we saw a reduction in 2.5 years in the biological age of the skin.
Dave AspreyHOST
29:37
Wow.
Carolina Reis de OliveiraGUEST
29:37
And we compared with rapamycin, which, you know, it's a very known, like, senolytic, and rapamycin was not able to reduce the biological age in a significant way.
Carolina Reis de OliveiraGUEST
29:47
So it was very interesting to see that by reducing senescent cells, we reduce inflammation, we reduce markers like IL 6, IL 8.

Unknown podcast

The Most Relaxing Facts About Aging to Fall Asleep To

Aug 30 · 1 Mention

speaker_4NARRATOR
166:47
They can release inflammatory signals and enzymes that disrupt tissue structure, which may contribute to frailty and age-related disease.
speaker_4NARRATOR
166:56
Senolytics are drugs designed to selectively remove these cells, like pruning overgrown branches so a tree can thrive.
speaker_4NARRATOR
167:04
In animal studies, clearing senescent cells has improved aspects of function in some contexts, which is why the field is so exciting.
speaker_4NARRATOR
167:13
Human research is newer.

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