Respiratory Physiology & Neurobiology

You know how many times? Every single time.

Twenty twenty-one Respiratory Physiology & Neurobiology confirmed this arousal threshold mechanism is so robustly designed by God that spontaneous respiratory-related death during sleep apnea events, zero.

Zero.

Your brain stem, just to give you the English version, uh, version, is a biological bouncer that will never let apnea...

Your pharyngeal airway is held open by, I already said, twenty-four muscles, right? This coordinated neural drive from all, from the nucleus in the brainstem, hypoglossal nucleus, the brainstem structure that fires this precise little synchrony to your respiratory rhythm generator, okay? So in obstructive apnea, sleep apnea patients, the signal fails.

Disproportionately fails, by the way.

The question nobody asks is why is the hypoglossal neural drive impaired? 2021 Respiratory Physiology & Neurobiology showed the hypoglossal motoneuron excitability is directly modulated serotonergic, noradrenergic, and orexinergic inputs.

Serotonin, norepinephrine, orexin.