renal cell carcinoma

Choice B, hematuria plus flank mass, wrong fucking answer.

That's gonna be RCC, renal cell carcinoma.

Okay? So a patient over fifty, smoker.

There's a painful flank mass and hematuria.

Same thing as with squamous cell carcinoma of the lung, and that gives you hypercalcemia.

So smoker over fifty, hypercalcemia, polycythemia, hematuria with, uh, flank mass.

Very buzzy for RCC, but the histo shows clear cells.

RCC is known as clear cell carcinoma.

2-naphthylamine is a dye that shows up on NBME.

Okay? So hematuria with a flank mass, such as choice C, that would be renal cell carcinoma.

But if you have hematuria and there's no flank mass, you wanna think it can be bladder cancer.

Both obviously can be caused by smoking.

But you memorize that.

So if they give you like a big paragraph, no image, and they say biopsy specimen shows intercellular bridges and keratin pearls, that combination is buzzy for squamous cell carcinoma of the lung, but clearly no pink circles here.

Okay? So, uh, this could also be renal cell carcinoma.

So renal cell carcinoma as well as squamous cell of the lung both secrete PTHrP.