RAGE

How does the nucleus know that, hey, I need to start making inflammatory molecules, that there's an infection going on, that there's something that's out of homeostasis? How does your chromosome know that? How does the nucleus know that? What message does it get? That message comes from a factor called NFK beta.

So where does that come from? Well, what happens is that these ages, they go to the cell receptor, which is called RAGES receptor for advanced glycation end products.

Stimulates that receptor on that cell.

That receptor sends a signal to the inside of the cell, which is this agent here.

So your DNA is bad.

It causes improper protein function.

Now, how does it do this? It goes to a receptor, which is on every cell in your body, called RAGES, right? There's receptor 2-AGES, and it's present in every cell of the body.

So, now, there's this agent here called methylglyoxal.