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Psilocybin

Psilocybin

Search complete. 62 mentions across 41 episodes found for "Psilocybin".

Sep 13, 2026

Eric OsborneGUEST
3:21
This is what I've been working with the most by far.
Eric OsborneGUEST
3:25
And psilocybin is unique.
Eric OsborneGUEST
3:26
Psilocybin mushrooms are unique in my opinion.
Eric OsborneGUEST
3:32
And they have always been, still are, and always will be, first and foremost, a spiritual tool.
Eric OsborneGUEST
3:44
Even in the book, I begin to argue, and one of the things I didn't expect about writing books that I love so much is that it's really helping me continue to evolve my thinking on the things that I think about.
Brittany FordHOST
11:30
Don't know if I'm saying that right, but...
Brittany FordHOST
11:31
Psilocybin itself is actually inactive, and your body converts it into psilocin, and this is what acts on the brain.
Brittany FordHOST
11:40
It is shaped almost exactly like serotonin, your mood and calm neurotransmitter, and it belongs to the same molecular family as serotonin, melatonin, and DMT.
Brittany FordHOST
11:53
That's why it fits into your serotonin receptors like a key that's cut almost the same.
Brittany FordHOST
16:10
You go down the hill, and you go in your toboggan, and you go down the same path over and over and over again, and that's what you know.
Brittany FordHOST
16:18
You know this same path over and over every single time you walk back up and you go down the hill.
Brittany FordHOST
16:24
Psilocybin is like a fresh blanket of snow on that hill, and now you're standing at the top of the hill and you're looking down and the possibilities of how you get down that hill are now infinite.
Brittany FordHOST
16:38
And it is actually remarkable how this plays out in real life.
EvanHOST
87:37
Again, these are absurdly safe substances.
EvanHOST
87:40
Psilocybin, LSD, and DMT are comically safe.
EvanHOST
87:44
It's like crazy how much you can consume and not have like, it's like basically impossible to overdose on these substances.
EvanHOST
87:51
People don't have heart attacks.
Linda BrubakerHOST
8:33
JAMA Insights article on the current evidence for psilocybin by Drs.
Linda BrubakerHOST
8:38
Rosenblatt and Hussain.
Linda BrubakerHOST
8:39
Psilocybin is metabolized to psilocin, which acts as a partial agonist of serotonin 2A receptors and causes perceptual changes, altered thought patterns, amplified emotion, among other quote psychedelic unquote effects.
Linda BrubakerHOST
8:55
Some key takeaways.
Linda BrubakerHOST
8:57
As of June 2026, psilocybin is not FDA approved for any indication.
Jennifer ChesakGUEST
2:35
What's going on? Yeah.
Jennifer ChesakGUEST
2:37
So I'm Jennifer Chesik, and I wrote the Psilocybin Handbook for Women's Health.
Jennifer ChesakGUEST
2:43
And it came out in 2023, and it's just been going gangbusters out there, which I've been really excited about, been on different podcasts and things like that.
Jennifer ChesakGUEST
2:53
But Going back in time, I was first really interested in psychedelics as a teenager.
CJ CowgillGUEST
42:55
So with the psilocybin though, um, psilocybin has a lot of benefits.
CJ CowgillGUEST
43:00
Number one, they're putting people under FMRI imaging.
CJ CowgillGUEST
43:05
Well under, um, Psilocybin, well, under the psychedelic experience.
CJ CowgillGUEST
43:10
And it is restoring gray matter in the brain.
CJ CowgillGUEST
43:13
Neurogenesis is happening.
Sierra CarterGUEST
12:21
I always tend to think that the medicine is a part of the discovery.
Sierra CarterGUEST
12:25
Psilocybin is one step to kind of opening our mind up to this mind-altering experience.
Sierra CarterGUEST
12:31
But truly, the participant is doing a lot of the work once the mind is open.
Joy Harden BradfordHOST
12:36
And how is it reacting in the brain, right? So I love that you gave the analogy of serotonin reuptake inhibitors.
Paul StametsSOUNDBITE_SPEAKER
31:28
I'm a mycologist, and that means I'm a scientist who studies fungi
Kai DickensHOST
31:32
Paul Stamets became famous for popularizing psilocybin mushrooms, and for him, these mushrooms are here to help change society undeniably for the better
Paul StametsSOUNDBITE_SPEAKER
31:40
Psilocybin makes nicer people.
Paul StametsSOUNDBITE_SPEAKER
31:41
They're less aggressive.
Paul StametsSOUNDBITE_SPEAKER
31:42
They're more empathetic.
Paul StametsSOUNDBITE_SPEAKER
31:43
They're kinder.
Paul StametsSOUNDBITE_SPEAKER
31:44
It reduces the excitement for aggression and makes people more contemplative, more respectful.
Paul StametsSOUNDBITE_SPEAKER
31:50
Psilocybin just turns down the dial so you're more reflective and conscious of what you're saying and doing
LizHOST
3:02
Okay
Brian ZapkoGUEST
3:02
... am too confused to your point, um, why, uh, psilocybin isn't here yet, or why we couldn't just try that.
Brian ZapkoGUEST
3:11
Psilocybin is being used in some other states out west, so, um-
LizHOST
3:15
Okay
Brian ZapkoGUEST
3:15
... it's medicalized out there.
Brian CzapkoGUEST
2:56
I'm not the best guy to speak to the legalities and the regulations of it.
Brian CzapkoGUEST
3:02
I am too confused, to your point, why psilocybin isn't here yet or why we couldn't just try that.
Brian CzapkoGUEST
3:11
Psilocybin is being used in some other states out west.
Brian CzapkoGUEST
3:14
So it's medicalized out there.
Brian CzapkoGUEST
3:16
I didn't know that.

31 more episodes mention Psilocybin.

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