Prochlorperazine

And that meant that I went too far in the other direction.

So I took Zofran and Compazine around the clock, not for three days, but for five days, just to make sure I would not throw up.

And unfortunately, it wreaked havoc on my colon.

Well, yeah, that was bad.

Now, we're careful how we talk about that.

So in normal use, the drug is Stemetil, and you use it for travel sickness as a tablet.

Um, we actually use a side effect of that drug when it's at very high concentration.

So we're not giving people tablets, we're giving IV over a short time into high concentration.

And once we figured that out, um, we started figuring, oh, we, you know, tr- use it for anxiety, use it for anything, right? So Thorazine came out and it was marketed for just about everything, 1954.

And then we had plo- uh, prochlorperazine, which is Compazine.

This is a medication that's st- I mean, Thorazine is still used.

I have used it.

And so Thorazine, we do still use it from time to time, but it is-- Rarely are you gonna have a-- You're not gonna have a new case of schizophrenia that, like, new 24-year-old comes out of the woodwork, and we're, we're probably not gonna end up using Thorazine on that patient.

This is something that's used more for folks that, um, nothing else has really worked for and they've been out there for a long time.

So Compazine, prochlorperazine, um, is used for nausea.

Is that-- That's typically where I'll see that.

When we're looking at migraine, uh, meds, we're often using abortive medications, so the triptan class of drugs, CGRP antagonists, antiemetic.

Like, a lot of times in the emergency room many years ago, I would often use an anti-inflammatory, so an NSAID, and also basically an antiemetic, whether it be Zofran or Compazine or something like that.

And a lot of times if I could give somebody early in the process of a migraine a liter of fluid, some medicine so that they won't vomit, and an anti-inflammatory, the vast majority of people could leave the ER when I was there without a headache then-

Wow