primary sclerosing cholangitis
DiseaseWikipedia
22
MENTIONS
11
EPISODES
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PODCASTS
Search complete. 22 mentions across 11 episodes found for "primary sclerosing cholangitis".
Sep 24, 2026
Livie WellsHOST
And this was back in 2018, 2019.
Livie WellsHOST
And, um, so he actually had d- diagnosed me with PSC, though, too, so that was a little different.
Livie WellsHOST
But he said, "I think it might also be PBC." So he was like, "You need to go to a hepatologist, and this is what you need to do." Um, so, um, mine kept coming back AMA negative.
Livie WellsHOST
I am a mutt, um, from the word go, so I am everything.
A. Jay FreemanGUEST
And then again, liver disease, we're definitely seeing an adult phenotype emerge.
A. Jay FreemanGUEST
We just had a kid here, 18, 19, that if I were to show any hepatologist just about in the country, they would have said PSC.
A. Jay FreemanGUEST
But you got to remember CFTR is only on the cholangiocytes.
A. Jay FreemanGUEST
It's not on the hepatocytes.
Christina G. GonzalesHOST
a left lower quadrant abdominal pain, especially in rectosigmoid involvement, and fatigue, weight loss, and severe disease.
Christina G. GonzalesHOST
Extraintestinal manifestations include arthritis, uveitis and episcleritis of the eye, erythema nodosum or pyoderma gangrenosum of the skin, primary sclerosing cholangitis or PSC, which is strongly associated.
Christina G. GonzalesHOST
Appropriate tip, bloody diarrhea plus rectal involvement equals UC until proven otherwise.
Christina G. GonzalesHOST
So how do we make this diagnosis? Well, a colonoscopy with biopsy is going to show us a continuous inflammation starting at the rectum.
Christina G. GonzalesHOST
Ulcerative colitis is the flip side of Crohn's.
Christina G. GonzalesHOST
It's continuous, mucosal, colon-only disease with bloody diarrhea as the hallmark.
Christina G. GonzalesHOST
Don't forget the PSC association and that colectomy is curative.
Christina G. GonzalesHOST
If this episode helped you solidify Crohn's versus UC, share it with your classmates and subscribe to the Pro PA Podcast.
Chris PeetzGUEST
Yeah.
Chris PeetzGUEST
So this-- We're talking about the Volixibat VISTAS-PSC study, uh, PSC to abbreviate the primary sclerosing cholangitis.
Chris PeetzGUEST
The results from that study read out earlier this year, very strong results in improving cholestatic pruritus in patients with PSC.
Chris PeetzGUEST
Background of the study is we designed it in dialogue with FDA where we had their input for this to be a potentially pivotal study.
Jennifer LaiGUEST
So a condition that your listeners might be familiar with is something called primary sclerosing cholangitis.
Jennifer LaiGUEST
That is a chronic liver condition for which we have, unfortunately at the moment, no cure.
Jennifer LaiGUEST
And so that is something where my patients with primary, with PSC or primary sclerosing cholangitis, I monitor them every year or every couple of years for their scarring levels so that we can talk to, so I can talk to my patients about, you know, if they are going to be developing cirrhosis anytime soon.
Jennifer LaiGUEST
Ideally, if the patient is diagnosed with a chronic liver disease, before they develop cirrhosis, we would try to cure that condition or control that condition.
Jennifer LaiGUEST
So, you know, someone maybe who drinks heavy alcohol and is having inflammation of the liver, we would advise them to stop drinking alcohol.
Silvia VillarinoGUEST
And I think that the non-invasive test will carry less risks and in some cases will provide the answer quicker than an invasive test.
Silvia VillarinoGUEST
The other two points I would like to make is regarding in adult pathology, there is groups where we talk about small duct PSC.
Silvia VillarinoGUEST
Most of these cases, if they don't have IBD, I highly suspect they might have a genetic cause for their liver disease.
Silvia VillarinoGUEST
There are several case reports from Europe and the U.S. where MDR3 deficiency was found in patients that had a presumed diagnosis of small duct PSC.
Silvia VillarinoGUEST
The other group is AMA negative PBC.
Silvia VillarinoGUEST
I think now that we have access to genetic testing, we will re- or we will revisit those diagnoses because I think some of them also might have a genetic cause for their liver disease.
Silvia VillarinoGUEST
So I think with time, maybe in five, 10 years, all of us will see less people with small dog PSC and AMA negative PBC diagnosis.
Silvia VillarinoGUEST
So this is an emergent field, and a lot of liver physicians, especially in adult medicine, are not super comfortable in deciding to pursue genetic testing many times because, as I mentioned, is the difficult access, but also the interpretation.
Robert G. GishGUEST
We don't have a way of predicting who is going to develop PBC now.
Livie WellsHOST
So is it, do women get it more, one, because potentially, I don't know, I'm just asking this question, are the women's biliary, the system, is it smaller? Are they smaller within the small parts of it, of that system? Or, you know, even, because I know PSC is the larger outer system, bile ducts.
Livie WellsHOST
So, and men tend to get that more.
Livie WellsHOST
So I'm wondering if it has to do with size by chance?
Josh DechHOST
You can get cirrhosis of the bile ducts.
Josh DechHOST
It's called PSC or primary sclerosing condylitis.
Josh DechHOST
It's just on and on.
Josh DechHOST
These symptoms can go.
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