
PPP2R1A
2
MENTIONS
1
EPISODES
1
PODCASTS
Search complete. 2 mentions across 1 episode found for "PPP2R1A".
Sep 28, 2026
Aprea Therapeutics - $APRE - Ep:079 - Nano Cap Podcast
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7:48Oren GiladGUEST
And then we reported one of the patients went for another scan and had additional 10%, so minus 55% tumor shrinkage with minimal side effects.
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7:58Oren GiladGUEST
And both had the same mutation, PPP2R1A.
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8:01Will ChernlinHOST
And so would you take this in conjunction with, say, like chemotherapy, but just have to take less chemotherapy and less side effects because you're doing a lot of the heavy lifting? Or is this a treatment all on its own?
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8:14Oren GiladGUEST
That exactly is the question that we're trying to address right now.
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9:18Oren GiladGUEST
One strategy is indication independent of the mutation, and that's USC, uterus serous carcinoma, because there's so much, there's high germ instability there that we do not need to pre-selectation.
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9:34Oren GiladGUEST
Then we have mutation independent of the indication.
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9:37Oren GiladGUEST
That's the PPP2R1A, FBXW7, cyclin E.
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9:42Oren GiladGUEST
Those patients that have, it can be prostate cancer, it can be breast cancer, it can be other tumor types, but they have to carry this mutation.