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PPP2R1A

PPP2R1A

Search complete. 2 mentions across 1 episode found for "PPP2R1A".

Sep 28, 2026

Oren GiladGUEST
7:48
And then we reported one of the patients went for another scan and had additional 10%, so minus 55% tumor shrinkage with minimal side effects.
Oren GiladGUEST
7:58
And both had the same mutation, PPP2R1A.
Will ChernlinHOST
8:01
And so would you take this in conjunction with, say, like chemotherapy, but just have to take less chemotherapy and less side effects because you're doing a lot of the heavy lifting? Or is this a treatment all on its own?
Oren GiladGUEST
8:14
That exactly is the question that we're trying to address right now.
Oren GiladGUEST
9:18
One strategy is indication independent of the mutation, and that's USC, uterus serous carcinoma, because there's so much, there's high germ instability there that we do not need to pre-selectation.
Oren GiladGUEST
9:34
Then we have mutation independent of the indication.
Oren GiladGUEST
9:37
That's the PPP2R1A, FBXW7, cyclin E.
Oren GiladGUEST
9:42
Those patients that have, it can be prostate cancer, it can be breast cancer, it can be other tumor types, but they have to carry this mutation.

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