porphyria

I really wanna dive deep into porphyria because when you read the symptoms, it's astonishing.

Walk us through a day in the life of a 16th century peasant suffering from this disease.

Porphyria is a group of rare inherited genetic disorders that fundamentally affect the nervous system and the skin by disrupting the production of heme in the blood.

For a peasant in the 16th century, the onset of severe cutaneous porphyria would be a waking nightmare.

nightmare.Because of the sunlight, right?

If you have toxic levels of heavy metals, that can lead to neuropathy.

Porphyrias, dysautonomia.

Uh, a B12 deficiency absolutely can cause a peripheral neuropathy.

Uh, idiopathic polyneuropathies, and you may know from my other videos on this channel that idiopathic means we don't know what the hell's causing it, but at least they can put a diagnosis on it.

Cutanea.

I think I said the same thing in our Porphyria episode.

I think I did the same thing.

Cutanea.

Cutanea.

Cutanea.

Porphyria cutanea.

Cutanea.