PNKP
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Search complete. 26 mentions across 2 episodes found for "PNKP".
Sep 10, 2026
Islam MohamedGUEST
It's headquartered in Calgary, and we're developing a first-in-class DNA damage response inhibitor against a novel target.
Islam MohamedGUEST
So that's a DNA repair enzyme called polynucleotide kinase phosphatase, or PNKP.
Islam MohamedGUEST
As far as we're aware, there is no clinical stage PNKP program anywhere in the world.
Islam MohamedGUEST
We hold exclusive worldwide rights to the University of Alberta's foundational PNKP inhibitor patents, together with an exclusive sub-license to the nanoparticle delivery platform that accompanies it.
Islam MohamedGUEST
Our lead candidate in this space is Onco10.
Islam MohamedGUEST
That's a combination of the PNKP inhibitor called A83B4C63.
Islam MohamedGUEST
And that's encapsulated within a nanoparticle to improve how long it circulates and how it accumulates in the tumor.
Islam MohamedGUEST
So in laboratory and animal studies, it demonstrates two distinct behaviors.
Islam MohamedGUEST
It's headquartered in Calgary, and we're developing a first-in-class DNA damage response inhibitor against a novel target.
Islam MohamedGUEST
So that's a DNA repair enzyme called polynucleotide kinase phosphatase, or PNKP.
Islam MohamedGUEST
As far as we're aware, there is no clinical stage PNKP program anywhere in the world.
Islam MohamedGUEST
And we hold exclusive worldwide rights to the University of Alberta's foundational PNKP inhibitor patents, together with an exclusive sub-license to the nanoparticle delivery platform that accompanies it.
Islam MohamedGUEST
So our lead candidate in this space is Onco10.
Islam MohamedGUEST
So that's a combination of the PNKP inhibitor called A83B4C63, and that's encapsulated within a nanoparticle to improve how long it circulates and how it accumulates in the tumor.
Islam MohamedGUEST
In laboratory and animal studies, it demonstrates two distinct behaviors.
Islam MohamedGUEST
In tumors that have lost a tumor suppressor gene, one called PTEN or P10, and another one called SHP1, It can kill cancer cells acting via synthetic lethality just with the drug alone.