Platelet-derived growth factor
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Search complete. 69 mentions across 25 episodes found for "Platelet-derived growth factor".
Sep 17, 2026
Steven HarrisGUEST
And then on top of that, you have the other treatments like stem cells, And moving up, you have polynucleotides, exosomes.
Steven HarrisGUEST
There was a platelet-derived growth factor, which was next, yes, PDGF, which of course has at the time, and I don't believe it has now, no random control trials in aesthetic medicine.
Steven HarrisGUEST
And the latest is peptides.
Steven HarrisGUEST
well, there's more actually, peptides, NAD.
Erin JensenHOST
Be consistent.
Erin JensenHOST
But if you don't do any of those things and you want to come in and do a treatment and add a little PDGF to your microneedling, I'm like, it didn't work.
Erin JensenHOST
It's like, yeah, it didn't work because you're not doing everything else along with it.
Megan PattersonHOST
Yeah, it's kind of like a heavy lift to – to put all that onto a syringe of PDGF.
Megan PattersonHOST
But when you're doing all those things, like you said, I think a lot of people get excited or enticed by the newest thing like salmon sperm, you know, or vampire facial or whatever, but they lay out in the sun.
Erin JensenHOST
Yes.
speaker_2HOST
Well, this is where we run into the massive biological limitations of traditional growth factors.
speaker_2HOST
I'm talking about things like PDGF, TGF-beta-1 and IGF-1.
speaker_1HOST
OK, let's slow down on the alphabet soup for a second.
speaker_1HOST
What do these actually do?
Ekta YadavHOST
Okay.
Drew TaylorGUEST
There's growth factors, some of which we know, PDGF, IGF-1, um, you know, um, uh, like VEGF, EGF, all of these different growth factors that hit different receptors on our cells and provide value.
Drew TaylorGUEST
Um, and I think that there's also adjacent to them these things called binding proteins.
Ekta YadavHOST
Mm-hmm.
Daylon JamesHOST
So that raises a lot of questions, not, not, not as a snipe or in the negative.
Daylon JamesHOST
I think the, the paracrine endocrine effect, is clearly underlying part of the potency of this approach, and they zero in on it with the notch and PDGF signaling.
Daylon JamesHOST
But this isn't like it's a organ-specific endothelium or something that's unique to the, to the bone, right? So it's, it's this generic endothelium, or maybe the generic endothelium is able to, to take on some of the phenotype of the bone-specific endothelium.
Daylon JamesHOST
Who knows? Point being is that you don't need like an intrinsic source of the endothelium, and I think that maybe is, is the opportunity here in terms of clinical translation, because obviously the scale we're talking about here being mice, it's macro, and that is a major step forward for sure.
Andreas HochhausGUEST
It does not inhibit KIT.
Andreas HochhausGUEST
It does not inhibit PDGF receptors, VEGF receptors.
Andreas HochhausGUEST
And the mutation profile, that means the sensitivity profile, is synergistic to a siminib and all the other drugs.
Andreas HochhausGUEST
It means ideal candidate for consecutive treatment, but also ideal candidate for a combination.
Algie LaBrascaHOST
Okay, so what else? There's another product that's kind of maybe there that you like.
Mystica LaBrascaHOST
Yes, so there's also something called PDGF, which is newer to the market.
Mystica LaBrascaHOST
That stands for platelet-derived growth factor.
Mystica LaBrascaHOST
And PDGF, it's recombinant, so it's made in a lab.
Mystica LaBrascaHOST
But PDGF is one of the growth factors that when we inject you with PRP and PRF that we are trying to stimulate in the hair follicle.
Mystica LaBrascaHOST
So this just skips the step of the blood draw.
Mystica LaBrascaHOST
And it's, it's comes from a lab.
Mystica LaBrascaHOST
It's only going to be as good and healthy as the patient.
John FrederickGUEST
Yeah.
Amy ChangHOST
So underneath the biostimulator umbrella, we have PRP and PRF, and then PDGF.
Amy ChangHOST
But let's start with PRP and PRF.
Amy ChangHOST
What are they, for the listeners?
John FrederickGUEST
They do not cause inflammation.
John FrederickGUEST
But they're working more through, uh, growth factors.
John FrederickGUEST
So PDGF, PRF, um, PRP, uh, all are using a growth factor to influence your body to make something.
John FrederickGUEST
Usually that's collagen, um, but technically a biostimulator.
Nicole BauerHOST
microneedling and the results were insane hyperpigmentation wise it was it was like beautiful so like even something like that paired together can be beneficial
Jon LeSuerHOST
Well, what I love is PDGF topically with skin pen microneedling.
Jon LeSuerHOST
That's me.
Nicole BauerHOST
I'm on my second one and my skin is like insane.
Jon LeSuerHOST
Thank you.
Jon LeSuerHOST
It's absolutely insane.
Jon LeSuerHOST
And anytime I do it too, I mean, I can't, we can't technically say that PDGF, like the data that it has doesn't show that it improves pigment.
Jon LeSuerHOST
But anecdotally with our patients, like I've had large melasma patches with patients.
Tammy PodlasekGUEST
Correct.
Tammy PodlasekGUEST
With the PDGF and the peptides.
Tammy PodlasekGUEST
All of that stuff too.
Tammy PodlasekGUEST
So hopefully next year it'll be a little heavier and not as heavy.
13 MINS LATER
ArielleGUEST
So I definitely think we're going to see more of that.
ArielleGUEST
Yes.
ArielleGUEST
You know, definitely figuring out the PDGF and everything that's going on with that.
ArielleGUEST
PDRN, all the P's that are.
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