Platelet-derived growth factor receptor A

Um, however, this is an evolving field, and I think the cImpact now, uh, uh, the 12th, uh, edition that was just, uh, released not too long ago, highlights that there may be many more alterations.

Uh, I'll give you an example of PDGFRA amplification, uh, MYC amplification, the presence of, uh, neuronal type of primitive neuronal elements, which can all push these tumors into a higher grade.

While TERT promoter mutation is being downgraded, if it's an isolated finding, that's no longer sufficient to call it a grade four astrocytoma, uh, in a non-enhancing or low-grade kind of setting.

So, uh, as you correctly mentioned, this is a, uh, ongoing and evolving field where we will learn more, and I suspect the subtypes of these tumors will become more defined, which will help us then prognosticate much better when we are discussing with the patient.