Phospholipase A2

And it doesn't impact the fact that most cardiovascular events, I'd say 60% are actually people throwing a clot.

And so no one's really looking at D-dimer and your clotting markers, not looking at HSCRP, homocysteine, PLA2, which is plasminogen activated factor.

They're not looking at a lot of these inflammation markers.

These are actually going to be really important because that's what predisposes someone to throwing a clot.

So that's a very important issue.

Are these, well, they're certainly not artifacts, but are they the result of a recovery from hypoxia? So there's a big increase in oxygen, therefore big increase in these particular type of lipids, right? These prostanes, or are they naturally produced controlling the prostaglandin-mediated events? Now, you can generate fatty acids off of phosphatidyl lipid using PLA2.

And PLA2 can also then allow for an activation of platelet activating factor acetylhydrolysis.

So that means platelets as well as immune cells are going to play a major role here in the production.

And why are we interested in plates? Because plates aggregate.

But there are certain biochemicals, especially some enzymes, which are valuable during the fetal development process.

And one of them in particular is called phospholipase A2 or PLA2.

It gets sequestered inside that nucleus pulposus.

And when you have like maybe just a small little crack or fissure in that annulus or a little bit of overall disc compression that causes that annulus to have a little bit of a disturbance to it, this does not have to put pressure directly on a nerve root that you would see in an imaging study, but you could have leakage of these substances out into the intervertebral canal.

And because they have been sequestered since fetal development, the body does not recognize them and treats them like a foreign substance.

And PLA2 in particular is neurotoxic.

So you can have excruciating back pain from a very minor degree of disc pain.

pathology that may or may not even show up well on an imaging study.