
Phoebe Liebling
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Sep 1, 2026
Osteoblast vs. Osteoclast Activity: How Estrogen Decline Drives Bone Loss
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23:56Jaclyn SmeatonHOST
or non-existent and I think you were in a more extreme case where you were diagnosed with early menopause or that like but even premature ovarian insufficiency that's not as severe as what you went through could be having an impact on bone health at this time where you're supposed to be building building building bone and not only are you building but you could be potentially losing absolutely because I

Phoebe LieblingGUEST
mean the way that I always I'm very visual And the way that I try and get people to understand, I guess, these more complex things is to really like think about them in like a visual way.

Phoebe LieblingGUEST
So I always describe the way that bone is kind of constantly turning over and you have your osteoblasts, so your builders and your osteoclasts, which are going to then be breaking down your bone.

Phoebe LieblingGUEST
And so estrogen stimulates, it's kind of like knocking on the door of the osteoblasts.

Phoebe LieblingGUEST
At the same time, as restraining the activity of those that are breaking down your bone.

Phoebe LieblingGUEST
So you then get a good ratio whereby you still need to obviously break down bone over time because you can't just be constantly building, but you want that ratio of activity to be swung, especially in those peak bone mass building years towards the osteoblasts being the primary ones that are working.
33 MINS LATER
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58:17Jaclyn SmeatonHOST
If someone's listening and they have osteopenia or osteoporosis and they really want to take this kind of proactive, nutritional, functional approach, what does reversal realistically look like for someone who's maybe already been diagnosed but really willing to commit to a good protocol?