PDE5 inhibitor
DrugWikipedia
18
MENTIONS
6
EPISODES
6
PODCASTS
Search complete. 18 mentions across 6 episodes found for "PDE5 inhibitor".
Nov 4, 2026
Max LugavereHOST
I mean, that's probably not something that's probably very much an off-label use of the drug, but...
Max LugavereHOST
I came across some research showing that sildenafil at least, which is a shorter acting, I guess, what is it, a PDE5? Is that?
Rena MalikGUEST
Yeah, PDE5 inhibitor.
Max LugavereHOST
Has a positive impact, at least in this one small study, on muscle protein synthesis.
Max LugavereHOST
And then there might potentially be all these like pleiotropic benefits that I think, you know, the data is still sort of shaky on that.
Max LugavereHOST
It leads to a really good pump in the gym.
Max LugavereHOST
And so, yeah, what are your thoughts on that?
Rena MalikGUEST
Well, so as a doctor, I can't recommend it off label, but I've looked at that data, and there is data on improving muscle protein synthesis, like you said, for PDE5 inhibitors, which is the class of medication.
George IbrahimGUEST
And I know I'm talking too long, but here's the last part of it.
George IbrahimGUEST
When you're in your 20s and you could do it whenever you wanted to, pretty much as often as you wanted to, those PDE-5, Viagra, Cialis, Levitra had not been invented yet.
George IbrahimGUEST
At 55, 50, 60, 70, you're not Viagra deficient.
George IbrahimGUEST
Sure, they can help, but that's not what you're deficient in.
18 MINS LATER
George IbrahimGUEST
Levitra, same thing.
George IbrahimGUEST
But food does play a big part.
George IbrahimGUEST
So if you're going to be taking a PDE-5, Viagra, Cialis, Levitra, whatever the new ones are, take it before you eat.
George IbrahimGUEST
huge um and then what else what was the other part of that question
RachelHOST
You may have come across phosphodesterases as treatment for other clinical conditions such as pulmonary artery hypertension or erectile dysfunction.
RachelHOST
There are 11 families of phosphodesterases and the ones found in platelets are PDE2, PDE3 and PDE5.
RachelHOST
Dipyridamol is a PDE5 inhibitor and is used for platelet inhibition in cardiovascular disease.
RachelHOST
The perioperative management of antiplatelets is also an examinable topic.
RachelHOST
Deciding to stop these agents is a balance of cardiovascular thrombotic event versus surgical bleeding risk and is done on an individualised basis.
Michael MehlmanHOST
Choice C, dipyridamole, correct answer.
Michael MehlmanHOST
So dipyridamole is a phosphodiesterase inhibitor, both PDE3 and PDE5, preventing the breakdown of cAMP, cGMP respectively.
Michael MehlmanHOST
And this is gonna result in vasodilation, blood vessels.
Michael MehlmanHOST
cAMP, cGMP both are vasodilatory, especially cGMP.
Michael MehlmanHOST
So it's a PDE3 inhibitor.
Michael MehlmanHOST
So dipyridamole is a longer word than cilostazol.
Michael MehlmanHOST
Therefore, dipyridamole is the one that inhibits both PDE3 and PDE5.
Michael MehlmanHOST
Whereas cilostazol, because it's a shorter word, it's the on- it's the one that inhibits only PDE3.
Jordan BarberGUEST
And then the thing is, you know, oh, it must happen to everyone 'cause the, the idea of, you know, Viagra is very common now.
Jordan BarberGUEST
All the PDE5 classification drugs, Cialis, et cetera, which increases blood flow, but why is the blood not flowing? And, and we could start even just hopefully for the practitioners thinking about Chinese medicine, we're saying blood flow.
Jordan BarberGUEST
W- and w- I already talked about the sinew channels.
Jordan BarberGUEST
We should say, "Huh, there's probably something else going on here." So I have a lot of young men, young 20s, 30s, 40s, who, you know, are having difficulties, and then they're trying PDE5s that some have side effects with.
Jordan BarberGUEST
And it's helping, but it's not the core issue.
Jordan BarberGUEST
And then you have the psychosomatic component as well, which what rules the sinews? The liver, right? So what is the smooth flow of chi? And we can start thinking about all these connections.
29 MINS LATER
Jordan BarberGUEST
But that's the thing you're taking.
Jordan BarberGUEST
When I'm assessing you, it's affecting you, right? So I use that, and I write to who you are, not to the pattern.
MagnusGUEST
And then I asked, "Okay, how about vacuum pumps?" "No.
MagnusGUEST
Uh, you can have sex, right?" "Yes." "Well, then you don't have ED, so then you don't need them." "Yeah, okay, but PDE5 inhibitors, I mean, uh, to, uh, to get the, the blood flow even better?" "Mm, no.
MagnusGUEST
You don't, you don't have ED.
MagnusGUEST
No."
MagnusGUEST
Yeah, yeah.
MagnusGUEST
And, uh, then he told me how to get, uh, the stuff, and, uh, he wrote, uh, uh, the recipe.
MagnusGUEST
So I got the PDE5, uh, the Tadalafil five milligrams each day.
Melissa Hadley BarrettHOST
Yeah.