Pathogen-associated molecular pattern
12
MENTIONS
5
EPISODES
5
PODCASTS
Search complete. 12 mentions across 5 episodes found for "Pathogen-associated molecular pattern".
Sep 14, 2026
Aleksander KragGUEST
So the, basically the barrier between what's going on in the gut and what's going to the liver is being affected by that.
Aleksander KragGUEST
It might mean some of these, what we call TAMPs and PAMPs, something disease or pathogen-associated components are actually driven to the liver, and that is driving inflammation.
Aleksander KragGUEST
And then you have this metabolic, this, this gut, and this direct effect that sort of all together is both driving steatosis.
Aleksander KragGUEST
But what is, what is driving the clinical liver disease is then inflammation, and in the end it's fibrosis, scarring in the liver.
Christian JenskiGUEST
And the reality is when you're talking about things like damage-associated molecular patterns, we call those DAMPs.
Christian JenskiGUEST
There's also pathogen-associated molecular patterns that we call PAMPs.
Christian JenskiGUEST
The best thing to understand from a layperson standpoint is that It's just creating a debris field.
Christian JenskiGUEST
And where there's tissue debris, there's also endogenous tissue, so your own self-tissue, where that debris field is.
Eric BalcavageGUEST
So when our own tissue is damaged or there's pieces of organisms that get into circulation...
Eric BalcavageGUEST
Those, we call them PAMPs or MAMPs, microbial associated molecular peptides and DAMPs, damage associated molecular peptides, which is our own tissue.
Eric BalcavageGUEST
They get into circulation, they bind to receptors on immune cells and that activates the immune system and says, hey, here's the piece of tissue that's been damaged.
Eric BalcavageGUEST
Go there and help, right? Activate the forces and go help.
Eric BalcavageGUEST
Now we know what we're looking for is the problem, essentially.
Eric BalcavageGUEST
And that's how we activate the immune system.
Eric BalcavageGUEST
But those same DAMPs, PAMPs, MAMPs are in circulation, but the thyroid cell itself has receptors for those.
Eric BalcavageGUEST
And when those particles bind to the thyroid cell's toll-like receptors, that initiates, it can convert the thyroid cell into an immune-like cell that it initiates its own immune inflammatory process.
David PerlmutterGUEST
We get that.
David PerlmutterGUEST
And so they're going to be called into action when there is some sort of threat, when there's a threat from a microbe, whether it's a bacteria or a virus, or perhaps there's trauma to the brain that releases certain types of chemicals, damage associated molecular patterns, damps or PAMPs, pathogen-associated, and then they're called into action.
David PerlmutterGUEST
Well, when you think about that, it's like the fireman who's called into play when there's a fire.
David PerlmutterGUEST
But it turns out that even the fireman does an awful lot when there is no fire.
Sam SmithHOST
And what they do is they actually bind to specific molecular patterns that are found within certain antigens or a certain pathogen.
Sam SmithHOST
And these patterns are called pathogen-associated molecular patterns, or PAMPs.
Sam SmithHOST
PAMPs.
Sam SmithHOST
And these PAMPs can include things like bacterial carbohydrates, specific nucleic acids from bacteria or viral DNA, bacterial peptides, peptidoglycan from gram-positive bacteria, and a lot of other kind of unique patterns that show up in different pathogens, whether that be bacteria, virus, or fungi.
Sam SmithHOST
To give you a quick real-life example, let's go back to the medium rare chicken that I ordered and then I ate.
Sam SmithHOST
I've got this salmonella that has invaded into my body, and the first thing that happens when it gets in there is that these PAMPs are gonna recognize it.
Sam SmithHOST
Now, what they're gonna recognize is they're gonna recognize a few different proteins in the flagella, specifically the Flg22 protein Of the flagella of that salmonella bacteria.
Sam SmithHOST
So it's kind of interesting, you know.