NLRP

So I think this has huge implications, right? Because, you know, we can effectively inhibit IL-1 beta, right? We have drugs which do that.

Uh, there's a, there's a fantastic paper many years ago demonstrating that the NLRP-1 inflammasome, which is also driven in that sort of scenario by IL-1 beta, you know, may contribute to the formation of, uh, asbestos, uh, inflammasomes, which then can drive asbestos-related malignancy and asbestos-related other conditions.

So the whole concept of IL-1 beta is in carcinogenesis, I think is really, really mission critical.

Uh, and there's an opportunity I see here to, you know, try and test that and drug that with IL-1 beta inhibitors.

I'm going to bring it in.

We're going to start talking about the NLRP inflammasome.

We're going to bring back the galactin system, the PDCE2.

We're going to talk about IgA production, and we're going to be discussing the T1, T2, and T17 CD4 positive T cells.

Now I'm bringing in more and more about the immune response.

And I'm talking about these various kinds of infectious diseases.

And we're going to look at how the signaling and the component of the transduction are going to be associated, even when we get back up into the, for example, central nervous system, where we're looking at neurodegeneration, such things as NLRPs are going to be coming back in, and of course, innate and acquired immune responses.

And yes, we're also going to find GAL3 there.

The cell is constantly acting Is something dangerous happening? Is there a pathogen? Is there cellular injury? Are there abnormal molecules? Is there mitochondrial dysfunction? Is there extracellular ATP? Are there damage associated molecular patterns? Are there pathogen associated molecular patterns? Is there something wrong with just the cell injury? entirely, right? The cell doesn't have a tiny security guard that's walking around with a clipboard, right? It has molecular sensors.

And one of the famous ones is called N L R P R N L R P three.

I said that wrong.

I said, I added another three and that stands for something extremely long, but I'm just going to say it once.

Okay.

And it's for what N L R P three stands for is not like, so N O D like receptor family pyrin domain containing three.

I'm not even going to keep on with that, okay? But the biology of this is quite interesting because that molecule NLRP3 activates and it causes, it has two stages.

One is priming and one is activation.