Myostatin

Today's listener question is very simple: If myostatin limits muscle growth, can follistatin remove that limit? Biologically, yes, at least in part.

Clinically, the answer becomes much more complicated.

Myostatin, also called GDF8, is a member of the TGF beta superfamily.

It binds activin type two receptors and activates SMAD two and three signaling inside muscle tissue.

The result is a signal that restrains muscle growth.