Myokine

Muscle communicates with the rest of the body.

So it communicates with the rest of the body by releasing signaling molecules called myokines during contractions.

Myokines influence inflammation, metabolism, communication between tissues.

And as estrogen begins declining through the menopause transition, women become more vulnerable to losing muscle and experiencing the resulting changes in insulin sensitivity and body composition, making resistance training and emphasizing muscle mass increasingly important.

Again, are you gaining weight in midlife due to your hormones? Or are you gaining weight in midlife because you never really spent the amount of time necessary to build muscle? Or maybe you're not currently even strength training to build muscle.

Do you think that there are other aspects of muscle that we should test? For example...

there's a lot of discussion now on myokines.

Myokines released from muscle through training, then having this inter-organ crosstalk, that it's also augmenting lipolysis.

You mentioned catecholamines, and every time I hear about catecholamines, I always think, should we have measured things like interleukin-6 or some of these myokines as well to further tell this story?

Yeah, I think you could go down... a rabbit hole of proteins to measure.

The body produces what scientists have called these hope molecules, but I think they're actually called myokines.

I think M, yes.

Myokines.

Myokines.

Yes.

All right.

Absolutely.

In fact, it is part of the concept of I train to produce something that is good, on a systemic level, so not only the muscle that grows, which is fine, but the muscle is an endocrine organ, so it impregnates substances called myokines, which are good for mood, sleep, skin.

Myokines? Myokines, they are cytokines, but myokines are nice, aren't they? I immediately forgot, though.

They do well.

I think it's right to look at physical activity in this way, so as something that does well to the whole body and also to the mood, as you said, the psychological aspect is very important, then in the life of a woman we don't talk about it.

So not only does it help our brain from the standpoint of challenging us through the movements we do and the training that we do, but it actually does support b- uh, cognitive function, memory, and reduces cognitive d- decline.

Myokines, uh, released during strength training signal the brain directly, and research shows consistent lifting reduces the risk of dementia and cognitive decline as you age.

Yeah, I'm gonna keep lifting.

It's gonna make me look fabulous and still be smart and, you know, with it.

It's a really cool mechanism.

Physical exercise forces the muscles to produce molecules called myokines.

Myokines.

Right.

These myokines cross the blood-brain barrier and act as an incredibly potent anti-inflammatory signal.

It's a really cool mechanism.

Physical exercise forces the muscles to produce molecules called myokines.

Myokines.

Right.

These myokines cross the blood-brain barrier and act as an incredibly potent anti-inflammatory signal.