Mucin-16
48
MENTIONS
31
EPISODES
25
PODCASTS
Search complete. 48 mentions across 31 episodes found for "Mucin-16".
Sep 18, 2026
Melissa HodeebGUEST
The biggest was actually in the UK of over 200,000 women.
Melissa HodeebGUEST
And they studied this, like, should we combine ultrasound and CA-125? Will we make a change? And what they found was, although there was a slight increase in detecting like earlier stage ovarian cancer, the most important take home is it didn't impact mortality.
Melissa HodeebGUEST
So we were not able to, you know, less deaths occurring from ovarian cancer, but what, What did happen in the women who had increased screening was some more harm, meaning patients were taken to the operating room at times for benign findings and not without risk.
Melissa HodeebGUEST
I tell patients all the time, I love surgery, but every surgery, even the most, you know, simplistic surgery has risks associated, right? And psychological harm, right? The need, I mean, think about, we've all been a patient.
Melissa HodeebGUEST
You're immediately, why, you know, do I have cancer? Oh, a hundred percent.
Melissa HodeebGUEST
The psychological risk that's associated is not something that's insignificant.
Melissa HodeebGUEST
And so the take-home point is that even with ultrasound and CA-125, the blood tests, we're not picking up cancers.
Melissa HodeebGUEST
You know, detection's not improved.
Dayna Ashley DorseyGUEST
So I haven't had any updates or anything, but If any family were to come forward or any new test or clinical trials, they are able to track it.
Dayna Ashley DorseyGUEST
Also, I want to say I did do a CA-125, which is not conclusive.
Dayna Ashley DorseyGUEST
You may have someone test very low, 10 to 20 mark, or you may have people in a couple hundred where I've had women that tested positive for cancer in the thousands.
Dayna Ashley DorseyGUEST
Clearly, there's something elevated in your body.
Dayna Ashley DorseyGUEST
Clearly, that's something I do probably every five years is CA-125 outside just my traditional blood work.
Dayna Ashley DorseyGUEST
And again, Marissa, as I spoke with you about getting a bus diagnosis, they might have told me I had cancer.
Dayna Ashley DorseyGUEST
Like, I was so dramatic.
Gottfried E KonecnyGUEST
So she started and is tolerating treatment well.
Gottfried E KonecnyGUEST
And we have early signs of decreasing CA125 and ctDNA dropping.
Gottfried E KonecnyGUEST
So encouraging.
Neil LoveHOST
Also, I notice here HER2 is 1+.
Mallory StuparichGUEST
It can decrease endometrioma size.
Mallory StuparichGUEST
And By looking at a blood marker called a CA-125, they've actually shown that people have a lower CA-125, which is sort of viewed as being this generic inflammatory marker in the blood.
Mallory StuparichGUEST
And so that's a supplement that I talk to a lot of patients about.
Mallory StuparichGUEST
It's over the counter.
Gottfried E KonecnyGUEST
So she started and is tolerating treatment well.
Gottfried E KonecnyGUEST
And we have early signs of decreasing CA125 and ctDNA dropping.
Gottfried E KonecnyGUEST
So encouraging.
Neil LoveHOST
Also, I notice here HER2 is 1+.
Gottfried E KonecnyGUEST
So she started and is tolerating treatment well.
Gottfried E KonecnyGUEST
And we have early signs of decreasing CA125 and ctDNA dropping.
Gottfried E KonecnyGUEST
So encouraging.
Neil LoveHOST
Also, I notice here HER2 is 1+.
Lori SillGUEST
He was like, I think there's a 10% chance this is probably just a uterine endometriosis cyst, like 10% chance.
Lori SillGUEST
And then he's like, let's run your CA-125 number, see what it says.
Lori SillGUEST
So I went down and did that.
Lori SillGUEST
And then that was a Tuesday, had surgery Thursday.
Lori SillGUEST
That CA-125 number was like in the 90s.
Lori SillGUEST
I'm at five now.
Mechelle WingleHOST
Okay.
Keith HopcroftPANELIST
And that was seemingly on the basis that while the test wasn't perfect, it was kind of the best we had.
Keith HopcroftPANELIST
And it just seems odd to me, couldn't the same case have been made for something else? For example, you could make the same case for CA125 and women worried about ovarian cancer.
Keith HopcroftPANELIST
why PSA was treated in this sort of slightly strange way?
Samuel MerrielGUEST
I don't know the full history of it, and I'm probably not quite long enough in the tooth to know the full history of how it all came about and things.
Samuel MerrielGUEST
It might be because prostate cancer is so common, like we're currently diagnosing 60,000 men every year.
Samuel MerrielGUEST
That's expected to go up to 80,000 by 2040, largely driven by our aging population.
Samuel MerrielGUEST
You know, whereas ovarian cancer in CA125, ovarian less common.
Samuel MerrielGUEST
It's relatively rarer.
Michelle LonerganGUEST
There is a blood test.
Michelle LonerganGUEST
It's called a CA-125, and it is used sometimes in, um, trying to make a diagnosis of ovarian cancer.
Michelle LonerganGUEST
But unfortunately, it isn't safe enough or foolproof enough, because over half of women that have an ovarian cancer diagnosis can have normal levels of this CA-125 in their blood.
Michelle LonerganGUEST
So it's not good enough to use for a screening program like we might suggest men have their PSA level checked for prostate cancer.
Michelle LonerganGUEST
It's, it's not good enough for the population.
Elizabeth TranGUEST
Okay, do the ultrasound, see if there's any masses, see if there's anything of concern.
Elizabeth TranGUEST
And if there is anything of concern, then there's something called CA-125, which is cancer antigen, and that's where it was the bigger red flag for me that it could have been cancerous before I even had the surgery.
Elizabeth TranGUEST
That's the frustrating part.
Elizabeth TranGUEST
I went to the emergency room, I went to the gynecologist, I went to all these different people to get scans, and no one knew what it was.
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