Morgan E. Levine

one clock disagreeing with itself.

A clock researcher, Morgan Levine, said it plainly in 2022.

In her words, we haven't proven that a change in the epigenetic clock is a change truly in your biological aging process.

and Luigi Ferrucci

a mortality risk predictor, you know.

And then Pheno Age was developed by my former postdoc Morgan Levine.

It's widely used.

pan-mammalian clocks.

That is one of the most reproducible findings in all of aging biology.

The most cited human data point on this comes from Morgan Levine, Valter Longo, and colleagues that published their work over a decade ago in the journal Cell Metabolism.

This was in 2014.

They looked at approximately 6,400 adults aged 50 and older in the NHANES-3 cohort.

And one of the ones from the second generation clocks that I like better is is actually, this is like 2018, 2020, 2018, yeah.

This was Morgan Levine, her pheno age, okay, that was based on real laboratory data.

And granted, that means it'll be fickle if someone's sick when they have it done, their HSCRP will be off and certain things, but it's at least more linked physiologically to the outcomes we care about so we can interpret better what it means and what to do about it.

Also, there are some issues with even the most recent epigenetic clocks, which has been studied by people like Vadim Gladyshev here at Harvard.