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Michael D. Yapko

Clinical psychologist and author

Oct 8, 2026

3:40
What, what-- how did those three come together?
3:43
Well, I hope it's not too long a story, but I was an undergraduate student at University of Michigan, and one of the ways to earn credits was to volunteer in some local institution of one type or another.
3:58
And Ypsilanti State Hospital was one of the choices.
4:02
Well, I'd never seen or been in a mental institution, a mental hospital to know what that was even gonna be like, but this was among the worst of the worst.
4:12
It was the kind of place where before you walked into a dark room, you would reach around the wall to flip the light switch so that all the cockroaches could run away.
4:21
It was just a terrible place of warehousing and dehumanizing people.
4:25
And I-- it made me angry, and I thought I could real- I can do better than this.

26 MINS LATER

29:59
Right.
29:04
Continue, please.
29:05
Isn't a gene for depression.
29:07
There are genes that make you vulnerable to depression, and the difference is we've moved away from genetics in this field into the domain of what's called epigenetics.
29:18
Epigenetics is the study of how environmental conditions shape genetic expression, and so family environment is an epigenetic force.
29:28
Psychotherapy is an epigenetic force.
29:31
COVID was an epigenetic force.
29:34
Environmental conditions that shape genetic expression.

21 MINS LATER

51:00
What would you say to them?

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