mesenchymal stem cell
67
MENTIONS
16
EPISODES
14
PODCASTS
Search complete. 67 mentions across 16 episodes found for "mesenchymal stem cell".
Nov 3, 2026
Rick JacobyHOST
And he was working on cancer at the time.
Rick JacobyHOST
And he was friends with Arnold Kaplan, who named MSCs stem cells and later named them 2017 as medicinal signaling cells.
Rick JacobyHOST
So Reardon took those ideas, went to Panama, a few stops along the way, and has a famous clinic called I've been there.
Rick JacobyHOST
I've seen his work.
GrokHOST
I'll check what regulators have said, along with the latest evidence.
GrokHOST
Rick, there is US literature using cord tissue cells, separate from cord blood.
GrokHOST
Duke published a small 2020 study where 12 children received umbilical cord tissue MSCs.
GrokHOST
It focused on safety, not proving efficacy.
Daniel CarruthersGUEST
Found it by accident.
Daniel CarruthersGUEST
As the story goes, she came back in after culture and MSCs and everything should have been dead and somewhere on the surface and they went from there.
Daniel CarruthersGUEST
So they're incredibly hard for them to figure out how to reproduce them.
Daniel CarruthersGUEST
At first, it took them a long time to figure out how to get enough for them to study.
Daniel CarruthersGUEST
Okay.
Daniel CarruthersGUEST
First, because they don't behave like regular MSCs.
Daniel CarruthersGUEST
They don't grow and expand like the MSCs that we work with, like the regular stem cells that everybody's working with, WJMSCs, placental MSCs.
Daniel CarruthersGUEST
Even to their highest level, like when they're growing in a lab on demand, like how we have them.
Reza JazayeriGUEST
And I've been very fortunate to do international lectures.
Reza JazayeriGUEST
And so I've learned a lot from, you know, everyone from all over, you can capture the fat cells, which again have a rich source of MSCs.
Reza JazayeriGUEST
And you put that again in to a composite that you inject into the tunnels.
Reza JazayeriGUEST
So your ACL essentially is really supercharged if you would, in that sense.
Benjamin KosubevskyGUEST
right.
Benjamin KosubevskyGUEST
He was the true discoverer of what we now call MSCs.
Benjamin KosubevskyGUEST
Um, so he comes out with these things and a couple of years later he goes, actually, I was wrong.
Benjamin KosubevskyGUEST
They're not really stem cells.
Benjamin KosubevskyGUEST
They can't become anything.
Benjamin KosubevskyGUEST
What we're really using is called MSCs, uh, mesenchymal stromal cells or medicinal signaling cells.
Benjamin KosubevskyGUEST
The name keeps changing, but MSC, the acronym has stuck.
Benjamin KosubevskyGUEST
And so pretty much from there, it's been that MSCs are signaling cells that when injected, tell your body, Hey, there's a lot of injury here.
Drew TaylorGUEST
So through simply plucking hair follicles from the back of the scalp, you can access these bulbs.
Drew TaylorGUEST
So if you've ever plucked an eyebrow, you see that white tip at the end, that is a cluster of cells that include high concentrations of MSCs.
Drew TaylorGUEST
You find them in bone marrow, you find them dispersed through your fat, and you also find them in the sheath and the bulge of your hair follicle.
Drew TaylorGUEST
And so this is the first way to really access this non-invasively.
6 MINS LATER
Drew TaylorGUEST
And there's very specific cells that are important to stimulate called the dermal papillae.
Drew TaylorGUEST
And this is like the very tip of that follicle.
Drew TaylorGUEST
It's a very specialized other type of stem cell other than MSCs that actually give rise to the shaft of the hair fiber.
Drew TaylorGUEST
Now, as we see with antigenic alopecia or any type of balding, those dermal papillus stop performing as well.
Adeel KhanGUEST
And then they're also smaller in size, so they don't get trapped in the lungs as easily when you do infusions or IVs for longevity.
Adeel KhanGUEST
Now, Most of them still do get trapped in the lungs, but compared to the regular stem cells, we're called mesenchymal stem cells or MSCs, 10x more can circulate.
Adeel KhanGUEST
So it's a big difference as compared to that.
Adeel KhanGUEST
So that's usually where we're comparing it to.
6 MINS LATER
Adeel KhanGUEST
Whereas Muse was discovered like 16 years ago.
Adeel KhanGUEST
So there's a lot more data in terms of understanding how the cell works and stuff.
Adeel KhanGUEST
And plus, Muse is a subpopulation of MSCs.
Adeel KhanGUEST
And MSCs have been studied for over 30 years.
Rick JacobyHOST
So today's episode is about that travel for me and my colleagues to this present state of what are called mu cells.
Rick JacobyHOST
And mu cells are highly concentrated, so to speak, MSCs, stem cells.
Rick JacobyHOST
But are they stem cells? Not really.
Rick JacobyHOST
They're signaling cells, and Arnold Kaplan, who originally named them mesenchymal stem cells, changed his mind, published that in 2017.
Rick JacobyHOST
So today, we're going to talk about these concentrated MSCs, signaling cells, whatever you want to call them, and also their derivatives of the microvesicles of them, which we call exosomes.
Rick JacobyHOST
So let me introduce Chat...
Rick JacobyHOST
Give the audience a rundown in the history of stem cells.
GrokHOST
That shift matters for your story.
StephanieGUEST
From there, you then resuspend either in You can go DMSO, bovine.
StephanieGUEST
I prefer MSCs.
StephanieGUEST
I think it's the most natural environment when you compare that to the human body.
StephanieGUEST
So I like that better.
9 MINS LATER
StephanieGUEST
Kind of.
StephanieGUEST
Also, because they have significantly better homing beacons.
StephanieGUEST
Not to say that regular MSCs don't.
StephanieGUEST
And I think the worst thing someone in this industry can do, even loving the Muse evolution, is to come in and trash MSCs.
Rick JacobyHOST
And let's discuss this from a signaling idea.
Rick JacobyHOST
What stem cells are? What MSCs are? Arnold Kaplan certainly needs to be in that discussion.
Rick JacobyHOST
I don't know if he ever discussed his prophetic use of the word medicinal signaling cells.
Rick JacobyHOST
And he's correct.
GrokHOST
Tuticum found part of that material in 1884 without the tools to understand it.
GrokHOST
like discovering phone parts without a phone network.
GrokHOST
Kaplan's key lesson is that MSCs often help by sending messages that shape repair, not by becoming replacement parts themselves.
GrokHOST
Then Dazawa's work on mu cells adds a wrinkle.
Rafael GonzalezGUEST
And that's where the finds started, where the whole sector, especially in the adult stem cell sector, went to, okay, the cells are signaling, or some of the context of the original people that actually did the findings of it, Arne Kaplan, was changing the term of mesenchymal stem cells to actually medicinal signaling cells.
Rafael GonzalezGUEST
So just as MSCs, but medicinal signaling cells, because they had long distance communication and they could signal to other cells to cause
Ross KopelmanHOST
a functional change.
Ross KopelmanHOST
That was a big find in exosomes.
6 more episodes mention mesenchymal stem cell.
Create an account to see the whole feed, search across every transcript, and follow the entities you care about.