Meningeal Tuberculosis

So that's why it's contraindicated for patients who have latent TB, unless they're treated in some sort of way, because the immune system is working with TNF alpha to try and prevent it from spreading.

Now, if we were to flip that around and say somebody has tuberculous meningitis, They only have a few number of bacilli in their CNS.

What they have is an intense inflammatory response that's trying to fight that bacteria in their CNS.

And that inflammatory response is a Th1 response.