melanoma
ConditionWikipedia
98
MENTIONS
55
EPISODES
51
PODCASTS
Search complete. 98 mentions across 55 episodes found for "melanoma".
Sep 10, 2026
Jared SheldonHOST
Oh, well.
Jared SheldonHOST
Melanoma, here we come.
Jared SheldonHOST
Don't say it.
Jared SheldonHOST
I'm well on my way.
MichaelGUEST
And this is important as well.
MichaelGUEST
Melanoma is the third most common cancer in individuals in their 20s and 30s.
MichaelGUEST
The third most common cancer.
MichaelGUEST
So it's just luckily people don't get it much when they're 20 and 30, right? But it's the third most common cancer.
Ahmad AmmousGUEST
However, melanoma, actually 75% of cases of melanoma tend to occur on areas that are not exposed to the sun.
Ahmad AmmousGUEST
So there's not really a clear correlation between melanoma and sunlight exposure.
Ahmad AmmousGUEST
Melanoma tends to happen in people who are unhealthy metabolically, who have immune system dysregulation that causes these melanocytes to grow out of, uh, proportion.
Todd PitnerHOST
Mm.
Ahmad AmmousGUEST
And actually, there is evidence to suggest that outdoor workers tend to have less risk of melanoma than indoors workers.
Jason GoldsmithHOST
I think they will sell some of this and they will save lives and it's all a win-win-win and super exciting, but how much are they gonna really sell given it's a one-off and not everyone, you know...
Brenda RaudHOST
Yeah, and also not every cancer, right? Melanoma has a lot of neoantigens that you can pick from, potentially, but there are a lot of other cancers that don't have such a mutated profile.
Brenda RaudHOST
That's going to be a little harder to use.
Brenda RaudHOST
I think they're also testing lung cancer, or colorectal cancer.
Gevorg TamamyanHOST
First at breast cancer, where she helped raise over $100 million from corporate partners, then at global disaster relief, moving hundreds of millions in medicine to places that had nothing.
Gevorg TamamyanHOST
Four weeks ago, she became the CEO of the Melanoma Research Alliance.
Gevorg TamamyanHOST
the largest private funder of melanoma research on Earth, an organization that has put more than $200 million into the field and helped bring 19 approved therapies to patients.
Gevorg TamamyanHOST
She took that job at possibly the worst moment in 50 years to be funding science in America.
Gevorg TamamyanHOST
And 90% of it, 90%, is preventable.
Gevorg TamamyanHOST
So why are the numbers going the wrong way? Why is a generation that grew up in Factor 50 now tracking the UV index to burn on purpose? And what does it actually take to turn science into something people care about? This is Stephanie Kaufman.
Stephanie KauffmanGUEST
It is such a pleasure to be with you and to have this discussion around why science especially matters more so today than ever, and the ability to share what we are doing at the Melanoma Research Alliance and how we want to make sure that funding is available for the incredible researchers that we are proud to support all around the world, but also to ensure that we can deliver More treatment options for patients and shorten that distance between the lab and to the patient.
Stephanie KauffmanGUEST
So I appreciate the opportunity to kind of share some perspectives today.
Jack LangtonGUEST
And for someone that deals with albinism, they need to go to a dermatologist.
Jack LangtonGUEST
Melanoma is the number one risk for them.
Jack LangtonGUEST
So getting the right care was something they really struggled with in that area.
Jack LangtonGUEST
Yeah.
Narayana SubramaniamGUEST
The reason for that is because immunotherapy and targeted therapy, specifically the checkpoint inhibitors, which are the group of drugs which the Nobel Prize was awarded for identifying, they have a very effective role in these kinds of cancers.
Narayana SubramaniamGUEST
Melanoma is one of the cancers which escapes the immune system and that's what leads to spread and mortality.
Narayana SubramaniamGUEST
So for patients who get treated for melanoma, the concern is, okay, we have upfront good response rates, but can we reduce the recurrence rates? So immunotherapy works.
Narayana SubramaniamGUEST
It prevents escape of the immune system.
Ira FlatowHOST
[upbeat music] Hey, it's Ira, and you're listening to Science Friday.
Ira FlatowHOST
A new mRNA vaccine for melanoma is making headlines.
Ira FlatowHOST
Moderna and Merck recently announced results from their clinical trial, which suggests that this new vaccine, in combination with another drug, significantly reduced recurrence rates of the skin cancer in patients.
Ira FlatowHOST
The companies have not yet released full data from the trial.
Ira FlatowHOST
So how does the vaccine work, and does this mark the beginning of a new era of cancer treatments using mRNA vaccine technology? Here to explain is a physician whose patients were part of the drug trial, Dr.
Ira FlatowHOST
Michael Postow, chief of the melanoma service at Memorial Sloan Kettering Cancer Center here in New York.
Ira FlatowHOST
Welcome to Science Friday.
Michael PostowGUEST
Thank you very much for having me.
Evan HansenHOST
I mean, you know, it does make me question a little bit of his movie watching choices.
Evan HansenHOST
So, Jeff, Jason and the Argonauts, or as it's known in some circles, Melanoma the movie.
Jeff SumogyHOST
Yeah.
Jeff SumogyHOST
Ah, the Sun of Greece? I'm guessing it was filmed on location.
JudeCORRESPONDENT
So researchers have been trying to find ways to stop cancers in other parts of the body from spreading and reaching the brain.
JudeCORRESPONDENT
Melanoma, lung, and breast cancer are the focus of this research, as they have the highest risk of spreading into the brain.
JudeCORRESPONDENT
Statistically, around 90% of melanomas end up becoming brain cancers.
JudeCORRESPONDENT
So to learn more about how cancer spreads to the brain, the research aiming to stop it, and how it works, I spoke to University of Auckland research fellow, Dr. Akshata Akshan.
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