Megestrol

By decreasing pituitary gonadotropin output, having a direct antineoplastic effect on the cells themselves, and through interference with estrogen receptor function.

The progestins that we use mainly are medroxyprogesterone acetate or Megace, medroxyprogesterone acetate or Provera and Depo-Provera, and levonorgestrel that comes in the Mirena IUD.

Next, let's discuss the estrogen-related agents.

Tamoxifen first.

Let's discuss practical use of these agents with three clinical scenarios: conservative management of uterine cancer and pre-cancer, recurrent and advanced uterine cancer, and ovarian cancer.

First off, uterine pre-cancer and cancer.

For fertility-sparing or non-surgical management of grade one endometrioid endometrial cancer, oral progestins, specifically Megace, give regression rates about ninety percent.

But with a recurrence rate of about 25%.

They make them out of the real stuff.

The companies have these huge farms growing wild yams in Mexico, and they make this progesterone, and then they deliberately alter it into Provera and Megestrol.

Now it no longer has the full range of activity, plus it's loaded with their toxic side effects.

That's what they're selling people.