Mdm2

The seventh area that we look at is DNA protection and repair, and this is the one people understand least, and I think it's quietly one of the most important.

The TP53, the tumor suppressor, sometimes called the guardian of the genome, And then there's ATM, MLH1, MDM2, XRCC3, plus the antioxidant genes that we talked about before, those combination of three.

SOD2, SOD3, GPX1 and catalase.

And what this section tells you is how well your cells repair the damage that happens to them every single day and how well you mop up the oxidative stress that can cause the damage in the first place.

And the pathologist usually will run certain panels.

You know, they might do a FISH for MDM2 or they might do some PCR or they might run a fusion panel for diagnostic purposes.

So that is important because that helps us know what the chemosensitivity is.

might be, or radiation sensitivity in some cases.

Didn't pan out for all of those subtypes.

And then you also have a lot that we see a lot of copy number alterations.

So, for example, the well-differentiated, de-differentiated liposarcoma will fall under that, that even though it's a spectrum of low-grade to high-grade disease, all of them have MDM2, and majority of them will have CDK4 that is amplified.

Multiple gene copies, not mutated, but it's an early amplification of this chromosome 12, a portion of chromosome 12.

Most definitely.

So, for example, NAV2 is an oral MDM2 inhibitor that activates P53.

Very active agent.

Has activity as a single agent in the relapse refractory setting.