How would you explain, Matthias, this to the cardiologists who may not be familiar with this field?

Yeah, Ricardo, I think you named the most important point, and that is that heart-brain crosstalk is truly bidirectional.

So heart and brain are not two independent organs that occasionally affect each other when something goes wrong.

They communicate continuously through neural pathways, autonomic nervous system, hormones, inflammatory signals, hemodynamic and mechanical signals.

So when this physiological communication is disturbed, in fact, disease in one organ can directly induce dysfunction in the other.

And we think that one of the most exciting and striking examples of this brain to heart direction is following acute stroke.

So typically we thought if something in the heart goes wrong after a stroke, that's just comorbidity.

Gray, could subtle alteration in autonomic and hemodynamic adaptation may represent one of the earliest footprint of cognitive impairment long before conventional neurological symptoms appear?