When did you first open the doormat on metabolic psychiatry? Did you hear it somewhere? Did you have an experience? What was the genesis?

Well, yeah, I mean, I've always been interested in, as we were talking about, like, you know, the exercise, physical body.

In my own personal life, I was disappointed that I wasn't able to get more people to do that as one of their main ways that they were getting treatment or getting better.

and uh you know i got really worried too prescribing all these medications that were causing all kinds of metabolic dysfunction in people and maybe making people gain weight and having their blood sugar be high and their cholesterol be high and um so that was always you know really bothered me that i would tell people then you kind of have to take this medication if you want to be mentally well and it was making them physically unwell you know that was always an issue for me um And then we had our experience in our family.

Two of my kids got sick with something that looks very psychiatric and it kind of happened all at once.

It turned out to be more of an autoimmune process.

And it really highlighted for me how In my field, because psychiatry didn't help them at all, it actually made them worse, which was hard to admit at the time.

yes.

Um, and so what is different? Why is ExxonMobil perhaps, um, choosing to, to pursue this strategy of growth, and maybe what about their portfolio enables it?

If you look at, at Exxon's goals, that two point five million that you referenced, that's two point five million barrels of oil equivalent per day in the Permian by twenty thirty.

So, you know, if you translate that from today, um, at one point eight, uh, you know, last year averaging one point six, I mean, you're really getting on a, a CAGR in the, the upper te- uh, upper single digit percentages there, whereas most companies, um, are really just kinda trying to either maintain and slightly grow production year on year.

So, um, very big difference there.

But w- w- the way that I see it is I, I think Exxon has both, you know, the right, uh, the right, uh, acreage to work with.

Um, they have the scale a-and they have the quality of scale.

So I mean, they're by far and away the largest, um, you know, acre... uh, inventory holder in the Permian Basin.

Um, Maddy, what does a higher gas price mean for, for activity in the basin?

I can't with that.

And, uh, yeah, she just kind of has become this MAGA darling very quickly.

She was take- courtside with Riley Gaines taking photos.

She's posting on Instagram with the caption, "I said what I said." And she's whipping this up, and she's getting more attention for herself than she's ever gotten as a basketball player.

Her Instagram following balloons to over two million, and then a couple weeks into this whole thing, she gives an interview, and she says, "I think we should go back to just talking about basketball." And you know why? Because she saw the tea leaves for her own career.

She saw what abject cruelty has done for the likes of Riley Gaines.

And she said, "I want a piece of that pie, because I am not going to be making a lot of money and getting a lot of attention as a basketball player for the rest of my life.

So let's talk about the Voting Rights Act, because there are a lot of Black people in the NBA and the WNBA, and the Republican Party is trying to dismantle their right to vote, but nobody talks about that because they talk about imaginary issues that don't fucking exist.

But Matt, why are we talking about this again now? Because who is Meta's latest collaborator?

Meta's latest collaborator, and to my knowledge, their only celebrity face thus far for the product, is a one Kylie Jenner, who has, they released with the official MetaGlasses release, which is, you know, separate from their previous Ray-Ban release.

There's like a few different styles that range from like starting at $300 to $400.

And the one celebrity collab style is Kylie, the Kylie Star Fire glasses, which do retail for the upper end of $400.

You know, she supposedly was like, helped design them and...

One of the selling points that they think is a selling point, I suppose, is that the chatbot that speaks to you from the glasses, which I don't know who's wanting this in the first place, it's in her voice.

And she was like in studio, kind of like audiobook style, just like reading a lot of words into, you know, what would be their AI system so that they could train the glasses to talk to you in Kylie Jenner's voice.

When you're at your like basest level, that's when she appears.

[laughs]

[laughs] Yeah.

Yeah, exactly.

But Mel Robbins, to her 12 million Instagram followers, did, um, a, a paid post with Microsoft Copilot, which is their AI tool.

Um, and the caption for it, without even getting into the context of the advertisement, the caption was like, "Women, stop being so afraid.

Because you know what's worse than being afraid of knowing how to start using AI? Being left behind." And then it goes on and on.

Yes.

You know? And, um, while the DHS/the US government does not currently have a contract with Meta around the use of these glasses, um, a growing number of ICE agents have been spotted wearing them so that they can easily record, um, either protesters they're clashing with, but more importantly, undocumented people, uh, who they are, wanna capture footage of to review later.

But Matt, why are we talking about this again now? Because who is Meta's latest collaborator?

Meta's latest collaborator, and to my knowledge, their only celebrity face thus far for the product, is a one Kylie Jenner, who has, they released with the official MetaGlasses release, which is, you know, separate from their previous Ray-Ban release.

There's like a few different styles that range from like starting at $300 to $400.

And the one celebrity collab style is Kylie, the Kylie Star Fire glasses, which do retail for the upper end of $400.

You know, she supposedly was like, helped design them and...

One of the selling points that they think is a selling point, I suppose, is that the chatbot that speaks to you from the glasses, which I don't know who's wanting this in the first place, it's in her voice.

And she was like in studio, kind of like audiobook style, just like reading a lot of words into, you know, what would be their AI system so that they could train the glasses to talk to you in Kylie Jenner's voice.

When you're at your like basest level, that's when she appears.

When did that first come onto your radar?

I was always a little skeptical of what we were doing in psychiatry with the whole neurotransmitter thing, and I wasn't excited about the functional outcomes we were getting, though we could get people out of their acute illness sometimes very well, and it was great, but then long-term people weren't doing well.

But I really got woken up because two of my three sons about nine years ago developed autoimmune encephalitis, or PANS, very acutely so basically their immune system started attacking their brain after infections and toxins and we got no help from the regular medical system i mean almost none and we had to go completely outside of regular medicine functional medicine environmental medicine really helped and along the way it was a many year journey i was learning all about all these different mechanisms and how much more there was that i didn't learn in medical school and residency Um, and then I was sitting in a lecture hall, um, at McLean listening to a grand rounds and Chris Palmer, who's really sort of like the, you know, the lead in metabolic psychiatry.

He was the one writing the papers first about 10 years ago.

Um, so this is probably about eight or nine years ago.

I'm sitting there and, um, he's talking about people with clozapine-resistant schizophrenia, that's the strongest medication we have, having their illness completely reversed by a ketogenic diet.

He was showing all the mechanisms and all the literature from epilepsy.

What was some of the evidence that was really compelling for you? And kind of what do you think the mechanism of action is actually going on here as we get people into ketosis?

Yeah.

But, like, Palestinian advocacy, it waits for nobody.

[laughs] Yeah.

Thank you for your tireless work.

[laughs] Thank you.

You're welcome.

That's so nice of you- You're welcome ... to take credit for your grandfather's letters.

Yeah.

And, um, I mean, what do you, how do you feel about it? I, I, we haven't really talked about it that much.

Yeah.

I, I, I have a lot of thoughts about it.

I mean, I, I, I actually added in some of my, like, solo thoughts at the end of the actual video in case people wanna watch it just about her answers to my questions.

But I think, you know, I, I actually don't think, despite the fact that I think we did a pretty good job with the interview of pressing her on, like, why do you support the Iron Dome, that was really what I wanted to ask her.

I was like, "Why do you support a two-state solution when that has never borne out in reality, and why do you support the Iron Dome? Uh, because you say you want peace, but how is that leveraging your status as a senator to, to create that reality?" And the thing about me that I think is, like, not cut out to do these sorts of things is that, like, I'm a very, very, like, soft person.

I always have been.

... you know, what do you think they thought your politics were? [laughs]

I'm amazed, and I'm so proud of you and so grateful.

Thank you.

Um, that is way more praise than I am personally willing to accept, but I do appreciate it.

I just feel like...

I mean, first of all, like, I credit everything that I know about, you know, Palestinian life and Israeli oppression to the Palestinians that I learn from every day, um, Mohammed El-Kurd, Bisan, Plestia, uh, Motaz, Omar Elakhal, all of these people who have been documenting a genocide, um, that they've been also living through, that their families have been living through.

Um, so yeah, I mean, it's funny what you said about, like, Sarah Hurwitz is making Jews less safe, and I get this comment all the time from Zionists saying that my being a Jewish person criticizing Israel, criticizing Israeli apartheid, criticizing now this, like, w- a state upheld by constant violence that's now leading the entire world into war, that that is making Jews less safe.

And to me, it is people like Sarah Hurwitz who inextricably tie, at every single opportunity, all Jewish people to the State of Israel.

Mm-hmm.

Sure.

...

I, I, you know, I think there is a lot of inconsistencies between what JK Rowling thinks she's doing and says she's doing and what is sh- she's actually doing, obviously.

And I think at the end of the day one through line for her is that, like, in her fight against abuse, in her fight against gender violence, like she decides what is gender violence and who commits it.

And she decides like who the problem is and who the problem isn't.

And so it's like, I don't know, I, I think she accuses obviously like a lot of trans people of being like violent men just by virtue of them being trans, but then also decides that like people with years and years of documented court tried abuse, like Johnny Depp, like Marilyn Manson, um, are not because like she, she, she can decide, you know? It, it is, it is strange.

She has a very, um, I do think she has like a, a godlike belief about herself.... um, which is evidenced also in the way that, like, she can never be wrong about anything.

Yeah.