Mannitol

It's seen on NCLEX.

Mannitol is the [gasps] only, there's those keywords, it is the only available drug, uh, given for IV use.

Mannitol is only available for IV use.

Contraindications and cautions.

When would we not give it? Mannitol is contraindicated patients with renal disease and anuria from severe renal disease, pulmonary congestion, intracranial bleeding.

That pressure, intracranial bleeding.

Make sure you read carefully when you're testing.

And then Tuesday morning, I go into OR and they go up my right femoral artery, all the way to the catheter, all up in my brain.

inject a chemical called mannitol.

Mannitol's job is to drop my blood-brain barrier.

Once mannitol is injected, my force feels now down, and it's not protecting from toxins, and they go up to that same catheter, inject chemotherapy directly in the brain.

The next day, they go to the left side and pick one of the three ventricles they didn't do the first day.

Osmotic agents.

Manitol and glucose.

They limit myocardial edema because an edematous heart is a stiff, poorly perfused heart after the clamp comes off.

And manitol is a free radical scavenger too.

In a study out of Belgium, they saw huge variations and the purity range.

And in the best case, you're getting a small amount of real peptide and a lot of mannitol.

Mannitol is one of the carriers that they often use in these peptide products.

In the worst case, you're getting... a whole range of other things, fragments of peptides, possibly other counter ions that is a part of the product.

In the Belgian study also, they looked at heavy metals and found that there was a substantial number were contaminated with levels of lead and arsenic above the regulatory limits.