major depressive disorder
Mental disorderWikipedia
164
MENTIONS
63
EPISODES
60
PODCASTS
Search complete. 164 mentions across 63 episodes found for "major depressive disorder".
Oct 27, 2026
Andrew TateSOUNDBITE_SPEAKER
You can choose to be depressed or you can choose to be a warrior.
Andrew TateSOUNDBITE_SPEAKER
Depression isn't something that happens to you.
Andrew TateSOUNDBITE_SPEAKER
It's something you allow because you refuse to fight back.
Andrew TateSOUNDBITE_SPEAKER
And that's exactly what's wrong with the world today.
6 MINS LATER
Ryan ReynoldsADVERTISER
Give it a try at mintmobile.com slash switch.
speaker_6ADVERTISER
telling you that you're wasting your potential that fire inside you instead of listening to it you drowned it out with distractions tv video games junk food mindless entertainment and then you have the nerve to sit there and say you're depressed you're not depressed you're
Andrew TateSOUNDBITE_SPEAKER
lost Depression is what happens when your soul is screaming for purpose and you ignore it.
Andrew TateSOUNDBITE_SPEAKER
Of you refusing to become who you were meant to be.
Ben EverettHOST
program with GH looking at 5-MeO-DMT.
Ben EverettHOST
So if we can talk a little bit about DT120 first, and I should say DT120-OD, because they've gone to that formulation, OD meaning orally disintegrating tablet, but DT120 is LSD, right? And they're looking at this form of LyserGuide or LSD in both MDD, so not treatment-resistant MDD, like what Johnson & Johnson looked at with S-ketamine spravato.
Ben EverettHOST
So they're looking at MDD and GAD.
Ben EverettHOST
It's been a very busy year for the program.
Ben EverettHOST
They've now reported three separate positive Phase III readouts.
Ben EverettHOST
Emerge, which was in MDD, Voyage, and Panorama, which were in GAD.
Ben EverettHOST
I believe they have one more in MDD that needs to read out.
Ben EverettHOST
So at a high level, can you walk us through what's going on at Definium?
Laura BilbaoGUEST
So basically what happened was that researchers were trying to explain or trying to find, let's say, if there was a difference between in symptoms of people that were all diagnosed with a major depressive disorder.
Laura BilbaoGUEST
So they all had the same diagnosis, but they were experiencing different symptoms.
Laura BilbaoGUEST
And what they did is they took 263 people that were diagnosed with MDD, with the major depressive disorder, and then they compared them to 75 healthy controls that they had.
Laura BilbaoGUEST
They used magnetoencephalography, which measures the magnetic field that our neurons make when they fire.
Laura BilbaoGUEST
So it's tiny, but it can be measured.
Laura BilbaoGUEST
diagnosis, but they were experiencing different symptoms.
Laura BilbaoGUEST
And what they did is they took 263 people that were diagnosed with MDD, with the major depressive disorder, and then they compared them to 75 healthy controls that they had.
Laura BilbaoGUEST
They used magnetoencephalography which measures the magnetic field that our neurons make when they fire.
Laura BilbaoGUEST
So it's tiny, but it can be measured.
BellaHOST
You don't even know any a topic.
BellaHOST
Nessie depression in today's relationship or say what are the causes and how do we solve it? Depression in today's relationship depression in today's relationship or say what are the causes and how do we solve it and as I'm say be a because okay or see a chem today in Tina a chem today.
BellaHOST
No, I better yeah and Sam yeah, any yeah, baby do who come on.
BellaHOST
Yeah kind of depression will treat more African depression will treat more deep depression.
11 MINS LATER
BellaHOST
Mm-hmm.
BellaHOST
Obi wɔ namabo sɛ natarime shima asasara- Mm-hmm.
BellaHOST
Depression.
BellaHOST
Ob damu nkyiti nti- Mm, Mm, Mm.
Terry LynchGUEST
I've written a book on this.
Terry LynchGUEST
I wrote a book in 2015 called Depression, Delusion, The Myth of the Brain Chemical Balance.
Terry LynchGUEST
I researched this in enormous detail.
Terry LynchGUEST
Joanna Moncrief, a British psychiatrist, published a similar book, I think, last year.
GinoHOST
also saw a...
GinoHOST
I mean, who doesn't love Clinical Depression, the animated series? Who's the...
JustinHOST
I'm not good with hockey teams.
JustinHOST
Who's the Ducks? Is it Anaheim?
Rheanna AviyHOST
It was published in JAMA.
Rheanna AviyHOST
And it studied adults with major depressive disorder, also known as MDD.
Rheanna AviyHOST
And it found a single dose of psilocybin given with psychological support reduced depressive symptoms compared with a placebo over six weeks.
Rheanna AviyHOST
But one thing about this is that the study used a supervised psychedelic dose, not microdosing.
Rheanna AviyHOST
Because as we know, microdosing is about taking very small amounts.
Rheanna AviyHOST
And the evidence for that is still mixed.
Rheanna AviyHOST
However, when you ask a person about microdosing and anxiety and MDD, they will tell you it helps.
Rheanna AviyHOST
That's what I found anyways.
AliGUEST
spiral.
AliGUEST
Depression is a spiral.
AliGUEST
Social anxiety is a spiral.
AliGUEST
Anxiety is a spiral.
Willard SpiegelmanGUEST
Levittown was a godsend to the middle classes because it gave people the ability to own a home, which they had not had.
Willard SpiegelmanGUEST
Mortgages, a regular mortgage in this country was a phenomenon only of the Depression, because before the Depression, if you had a mortgage on a house, you paid off only the interest.
Willard SpiegelmanGUEST
It was not amortized.
Willard SpiegelmanGUEST
So amortization of mortgages is a relatively recent phenomenon.
53 more episodes mention major depressive disorder.
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