Lymphocyte-activation gene 3

I mean, it seems that at the third stage you're seeing the T effector memory go up, the T reg go up, um, and then a TH17 go up, and then it drops off this cliff.

And I think, like the exhaustion markers that they point out, CTLA-4 and LAG-3, they really just rise, and then you see a real intensity, particularly of IL-21, of LAG-3, STAT4 in that L4 level.

So sort of the, you know, we talked about the little bit of a contraction, but also this, um, maybe there's a sort of parallel to what I tried to bring up with the B cells, with almost this exhausted regulatory-

Mm

This has shown that starting with the mouse leukemias, there is indeed gross perturbations of the tumor microenvironment with alterations of Icarus.

We see perhaps a reduction in the absolute number of T cells, but a marked expansion in the number of memory and exhausted T cells as shown here, with expression of markers of energy and exhaustion, PD-L1 and LAG-3.

The same thing in human leukaemias.

We've profiled a number of different human pH-positive leukaemias at baseline that show the same thing, expansion of an exhausted and anergic state.