LRP5
ProteinWikipedia
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Search complete. 4 mentions across 2 episodes found for "LRP5".
Oct 29, 2026
Don D'AmicoGUEST
And then the ability to mimic Norin, which is the natural agonist is very difficult.
Don D'AmicoGUEST
You have to activate a Frizzled IV receptor while simultaneously activating two LRP5 epitopes.
Don D'AmicoGUEST
And it's been a real challenge, but recently Remig-Remig is successful in achieving this very complex activation.
Don D'AmicoGUEST
As a result, one can think of it as a, essentially a Band-Aid, if you will, or a repair of the blood retinal barrier, which is quite different than, you know, inhibiting new vessel growth, et cetera, with anti-VEGF.
Donald J. D'AmicoGUEST
So you're trying to make a compound that has enormously complex and it's unstable.
Donald J. D'AmicoGUEST
And secondly, you have to activate the Frizzled 4 receptor and two epitopes of LRP5 simultaneously.
Donald J. D'AmicoGUEST
And this had stymied a lot of attempts.
Donald J. D'AmicoGUEST
There was great interest in agonizing the wind pathway, but Remig-Remig achieves that complex activation.
Donald J. D'AmicoGUEST
It's a tetravalent tri-specific antibody.
Donald J. D'AmicoGUEST
So it's really innovative.
Donald J. D'AmicoGUEST
Two of the sites go to the Frizzle 4 receptor, and it kind of grabs them together, and that allows it to reach the two LRP5 epitopes.
Donald J. D'AmicoGUEST
And, you know, it's something of a triumph that we have an agent that we can inject in the eye as a neuron memetic, which I've said has been, you know, really a goal for many, many investigators for a long time.