IRS1

Our results showed a positive but statistically non-significant correlation between African ancestry and HOMA-IR in line with an earlier study that demonstrated that children with greater African ancestry had lower insulin sensitivity and a higher acute insulin response in genome-wide scans to date.

The majority of the genetic variants for type 2 diabetes identified in European-derived populations appear to be related to impaired insulin secretion, while only IRS1 has been unequivocally associated with insulin resistance.

Uh, however, a limitation in these studies have been carried out largely in Europeans, or a limitation in these studies have been [gibberish] It would be interesting to explore whether the loci associated with two type 2 diabetes in African Americans are also associated with impaired insulin secretion.

Uh, one genome-wide association study with sufficient power are carried out.

So here's the mechanism of these ceramides and these DAGs, right? These diacylglycerols.

So here, because they fill the cell, right? So these ceramides physically interfere with the signaling protein IRS1, insulin receptor substrate 1.

So think of Think of IRS-1 as the message receiver inside the cell.

It's like the catcher ready for the ball, right? Even if the insulin successfully unlocks the door with the receptor, the signal can't propagate inside the cell to tell the GLUT4 doors to open.

It doesn't work.

And they aren't even using small molecules for this.

They are using RNA interference to target genes like IRS1 and GCK.

Because if you understand the causal human genetics, you can use RNA interference,

which is