iPLEDGE program

It, it is a, it is a- Very good option, strong recommendation for this, for isotretinoin for that severe inflammatory acne.

So let's talk about that and the role of that a little bit more, and then also what are some of these changes that's coming with the iPledge REMS program that we need to be aware of?

Yeah.

Yeah, so you're right.

You know, it has an important role for treating severe treatment-resistant acne as well.

But in terms of safety, that efficacy comes with the potential for a profound, pretty embryo fetal toxicity risk.

So that is why we have our iPledge REMS.

Mm-hmm, mm-hmm.

W- During the trials, a couple people committed suicide, and so you have to enroll them in a REMS program.

Similar to, like, IPledge, you have to enroll them into a program like that because of this suicidality risk.

Some people, it's very debated.

You know, this is kind of like one of those debated things, but that's something that you have to know about.