International Journal of Molecular Sciences

And this is a more recent one, November 2025, so just over a year ago.

And this was in the International Journal of Molecular Sciences.

And the title is Exploring the Potential of Molecular Hydrogen in Different Heart Failure Models.

They say this is the first comprehensive review of molecular hydrogen's effects in various heart failure models.

And we're looking at a stack of heavy hitting sources to do just that.

We've got clinical reviews from current oncology reports, biological data from the International Journal of Molecular Sciences, and some incredibly grounded clinical insights from Dr. Gary Deng, who is an integrative medicine specialist at Memorial Sloan Kettering.

So real science, not just marketing hype.

Exactly.

So the immune system is perfectly healthy, but it just walks right past the tumor without even seeing it.

Exactly the problem.

But studies published in the International Journal of Molecular Sciences have shown that Ganoderma extracts can actually reduce the expression of those PD-1 proteins.

It disrupts the handshake.

Here is an interesting research note on MK7 specifically.

A review published in the International Journal of Molecular Sciences found that MK7 has meaningfully higher bioavailability than MK4 at nutritional doses and is exactly what drives the bone mineral density and bone quality benefits associated with K2.

So in plain terms, if a K2 supplement doesn't specify MK7 on the label, it might not be the form doing the most amount of work that you are expecting.

So seek that out.

So they tested this out.

This was published in the International Journal of Molecular Sciences.

Very good journal.

In the year 2022, the researchers are based out of Russia.

Refining does extend shelf life and creates aesthetic uniformity, but it sacrifices the phytochemical fingerprint that gives jojoba its anti-inflammatory properties.

Research published in the International Journal of Molecular Sciences shows that unrefined jojoba contains gaudeleic acid metabolites that inhibit inflammatory cytokine production.

You won't find those in ultra-refined prestige oils that have been engineered for cosmetic elegance over therapeutic efficacy.

Trader Joe's is basically gambling that consumers care more about molecular integrity than marketing aesthetics.

And there's been a long-standing concern that these same compounds might interfere with thyroid function, that they're goitrogenic.

But a 2024 systematic review in the International Journal of Molecular Sciences looked at 123 articles and concluded that the vast majority of results cast doubt on the assumption that brassica plants have antithyroid effects in humans, provided iodine intake is adequate.

So that worry is largely overblown.

It seems to be, yes.

But of course, oxidative stress then produces the reactive sugar fragments that drive glycation.

Charlotte Delrue and colleagues laid this out wonderfully in a review they published in 2023 in the International Journal of Molecular Sciences.

And they traced how AGEs and RAGE contribute across all of the rheumatic diseases, rheumatoid arthritis, lupus, Sjogren's syndrome, and juvenile arthritis, among others.

One consistent signal in that literature is worth noting for a moment.

So, in type 1 diabetes, you have glycation biology and inheritance pointing at the same receptor.

I want to be careful and honest about the limits of this mechanism, however, because that is how this particular series earns your trust over time.

Alexandra Eichhorst and colleagues in 2019 published a study in the International Journal of Molecular Sciences, and in the study, they deleted rage entirely in mouse models of lupus and arthritis to see what would happen.

The RAGE-deficient mice showed a tendency toward lower autoantibody levels, which fits the idea that RAGE promotes the self-attacking response.