Insulin-like growth factor

So what ends up happening as far as the greasy skin is concerned is it ends up becoming just a result of those androgens.

But additionally, when IGF is also elevated as a result of insulin, so IGF is insulin-like growth factor, When IGF gets elevated, this is a very pro-growth thing, which can be good for recovery.

But as we get older, it's not necessarily something we want circulating at high levels.

That happens.

But additionally, what has been demonstrated to happen is with hyperinsulinemia, you also end up having a decrease in the IGF binding protein.

So you have higher levels of circulating IGF with less places for that IGF to go.

Now, when this happens, it sort of deforms and throws a wrench in sort of the proliferation and the apoptosis of various keratinocytes, so the skin cells.

And when that happens, you have skin cells that are dying when they shouldn't die, skin cells that are growing when they shouldn't grow, and you have this imbalance.

Yeah, yeah.

I mean, it probably isn't the perfect analogy, but kind of like the same way that CRM IGF-1 is not dictative of localized IGF-1 and growth in the muscle there.

Is that because muscle cells convert GH to IGF-1 intracellularly as well?

I'm not really sure, man.

I don't know.

But I think the discussion is just that, like if you ever get your blood work done and you get your IGF-1 levels, obviously that's serum IGF-1, not localized.

So it's not, some people think that there could be a correlation, but it's not really, you just have no idea how much IGF-1 is actually, I guess, in your muscles or being utilized for growth.

And then there was some kind of, I don't remember what the conversation was, but maybe it was Tren where Tren, actually reduces your serum igf1 but what maybe it potentially potentially like allocates that towards your localized igf1

It turns out people can get much, much stronger.

Their body comp may not change, but they'll also see muscle hypertrophy and altered changes in these special proteins called IGF-1s, insulin growth factors.

So, lo and behold, resistance training.

Good for you.

They give you energy.

So they stimulate the mitochondria and they stimulate something called IGF.

Now the title IGF is not that important as what I want you to know.

And I will link the study in here is that when you have a deficiency in IGF in your body, it contributes to metabolic syndrome.

So we want to keep IGF high.

And the number one way you can keep IGF high is through amino acids.

So with that in mind, how would you know if you have an amino acid deficiency? So here are some of the classic symptoms and I'm kind of curious as I read them out, if you guys resonate with this, we see your comments here on YouTube and the Resetter Collaborative on Facebook.

And we know some of these things you guys are experiencing and we don't want you to stop fasting, but we want you to lean into more amino acid foods.

Growth hormone is an insulin antagonist, 'cause insulin wants to store energy, growth hormone wants to mobilize it.

Now of course, between the two, we have insulin-like growth factor one in particular, although there's more, there's two and three.

But the IGFs are a little more on the side of, of acting like insulin acts.

But opposing some of those actions, but, uh, uh, facilitating others, is growth hormone itself.

So in pregnancy, the insulin resistance is a product of growth hormone and progesterone.

Okay, I'm not saying that.

What I'm saying is the food that you eat when you're eating an- when you're eating animal-based foods, that that saturated fat triggers your liver to make an abundance of IGF-1, and we know IGF-1 speeds up the growth of cancer cells.

Yep.

And, and, and s- and so if you've got cancer, you want your IGF-1s- levels to be as low as possible.

The way to do that is a whole food plant-based diet, and when you do that, you can literally slow down the growth of cancer.

Because the, the important thing to understand with cancer is that when we say it's a chronic disease, it can take 20 years, it can take over 20 years for that first malignant cell to, to, to multiply enough where it can even be detected.

It's that that's complicated.

Um, because there's a negative correlation between, uh, um, IGF levels and longevity.

So the, the higher an animal's IGF levels are the typically the lower, the shorter their lifespan is.

Yes.

Um, but then you have to factor in quality of life as well.

Yeah.

There's more blood circulation in the muscle than there is subQ.

So it's a faster spike of GH and then downstream IGF.

What would I rather? I'd rather the one and a half grams and the GH, without doubt, without question.

And I think, like, that for me, the IGF sort of maxing protocols, so for example, like let's say things like Incaix, high dosage GH, insulin pathways, for me, I feel like that's kind of a game changer for my physique in regards to, like, what really has made me go from, like, being all right to being pretty decent.

Now shit as a pro, but shit.

But [laughs] you know what I mean, when it came to, like, trajectories.

Yeah.

I, I, I- So what is your, what would you recommend to someone to get the most out of their HGH usage? And what would you say to avoid the mistakes of-

I'd say, I'd say all pre-med, um, you get highest amount of IGF conversion, blah, blah, blah with dose.

Don't split it up unless you get sides from running it high in the evening, but then I'd argue you could look at actually the reason why you're getting sides.