hypercalcemia

also on the flip side too much of vitamin a can create symptoms that mimic a deficiency of vitamin a abnormal bone formations dry lips dry skin double vision alopecia oily skin peeling skin Heart valve calcification, which could be a big problem.

Hypercalcemia, too much calcium in the blood.

Normally too much vitamin D will do that, but vitamin A is also involved.

Another one is intracranial pressure.

Now, there are many signs and symptoms of calcium imbalance, and some of the most significant are cardiac-related.

Hypercalcemia can cause bradycardia and cardiac arrest, while hypocalcemia can cause heart blocks, ventricular fibrillation, and torsades de pointes.

It's also important to know that hypocalcemia can cause laryngospasm with stridor that can lead to respiratory arrest.

The next component of our basic metabolic panel is chloride.

Lupus perneo, chronic violaceous facial lesions and a clue toward chronic disease.

Hypercalcemia, think extra renal vitamin D activation by granulomatous macrophages.

Facial nerve palsy, think neurosarcoidosis.

Unexplained high-grade AV block or ventricular arrhythmia, think cardiac sarcoidosis.

Because digoxin has a notoriously narrow therapeutic index, the calcium swings inherent to titrating or discontinuing this drug can be highly problematic.

Hypercalcemia increases intracellular calcium, which can precipitate digitalis toxicity and arrhythmias.

And if calcium falls, it reduces digoxin efficacy.

Right.

And what did they find?

They found that daily doses just approaching that limit, around 3,200 to 4,000 IU, already begin to carry an elevated risk of adverse events, primarily hypercalcemia.

Hypercalcemia, too much calcium in the blood.

Explain the physical mechanism there.

Because D3 acts like a key unlocking those intestinal gates, does taking too much leave the gates permanently open?