Skip to main content
Holden Karnofsky

Holden Karnofsky

Former CEO of Open PhilanthropyWikipedia

Search complete. 19 mentions across 15 episodes found for "Holden Karnofsky".

Oct 19, 2026

Dr. BobHOST
22:51
Ms. Tuna is on its board, as is an executive at the trading firm Jane Street.
Dr. BobHOST
22:58
So is Daniela Amadei, who's married to GiveWell's co-founder Holden Karnofsky, now working at Anthropic.
Dr. BobHOST
23:07
Amadei is the co-founder and president of Anthropic and sister of Anthropic CEO Dario Amadei.
Dr. BobHOST
23:16
EA has had some big bang moments, like the implosion of Sam Bankman-Fried and his colleague Caroline Ellison, who met at Jane Street and, motivated by effective altruism, tried to strike it rich and do good with it, or so they claim.
Razib KhanHOST
26:27
Well, I will tell you, I don't think I can say this because this is a long time ago.
Razib KhanHOST
26:32
I remember having a long discussion in Holden Karnofsky's car because he was dropping me off to my apartment in Berkeley in 2010.
Razib KhanHOST
26:43
I believe it was the spring.
Razib KhanHOST
26:44
I'm just like thinking of the weather.
Joe BerquistHOST
12:15
That same year, Amodi stumbled on a link on an economic blog that led him to a nonprofit charity evaluator called GiveWell.
Joe BerquistHOST
12:24
Uh, founded the previous year by former Bridgewater Associates hedge fund analyst Holden Karnofsky and Elie Hassenfeld, uh, it aimed to help donors maximize the good done per dollar donated, usually measured in lives saved.
Joe BerquistHOST
12:40
Uh, Amodi began leaving comments on the GiveWell blog and once guest blogged on it directly.
Joe BerquistHOST
12:46
In the 2010 post, uh, he deployed utilit-utilitarian reasoning while weighing whether to give 10,000 to one charity rather than another.
speaker_4HOST
17:19
Yes.
speaker_4HOST
17:19
GiveWell was a charity evaluator founded by a man named Holden Karnofsky.
speaker_4HOST
17:23
Karnofsky was basically the central hub, the chief accountant for the early effective altruism movement.
speaker_3HOST
17:30
So you have this collision of titans.
speaker_4HOST
19:09
You had Chris Ola, another foundational, globally recognized AI researcher.
speaker_1ADVERTISER
19:15
Wow.
speaker_4HOST
19:15
And of course, Holden Karnofsky, who would later marry Daniela Amidoy and become Dario's brother-in-law.
speaker_4HOST
19:20
It was a closed loop of the highest IQ individuals in the Bay Area.
speaker_1HOST
3:23
And you have a Princeton physics PhD student named Dario Amadei, who is heavily absorbing Yudkowsky's probability models back in 2008.
speaker_0HOST
3:32
And she eventually connected with Holden Karnofsky, who co-founded a charity evaluator called GiveWell.
speaker_1HOST
3:38
Yeah, and by 2013, Karnofsky had literally moved into Amodei's group house near Glen Park in San Francisco.
speaker_0HOST
3:44
So that Glen Park house was effectively the incubator for the modern AI safety movement.
Type 3 AudioNARRATOR
5:04
I agree, and effective altruists have been saying so for years.
Type 3 AudioNARRATOR
5:09
In 2022 Holden Karnofsky, a co-founder of GiveWell, wrote, I think it's a bad idea to embrace the core ideas of EA without limits or reservations.
Type 3 AudioNARRATOR
5:19
We as EAs need to constantly inject pluralism and moderation.
Type 3 AudioNARRATOR
5:23
My own PhD focused on moral uncertainty.
Rob WiblinHOST
3:13
Yeah.
Rob WiblinHOST
3:14
Is it basically all AI all, all the time these days? I think o- one of your colleagues, Holden Karnofsky, who's also been on the show before, uh, used to work on a wider range of issues, but recent, recent events have prompted him to narrow his focus somewhat.
Rob WiblinHOST
3:26
Has, has the same happened to you?
Ajeya CotraGUEST
3:27
Certainly for me, it's all AI all the time, and it has been for three years or so.

1 HR 51 MINS LATER

Rob WiblinHOST
114:46
... that's working on practical tests for whether a model is safe that potentially could be applied to all kinds of models, uh, b- before they get deployed.
Rob WiblinHOST
114:55
And I think the, the hope that they have is that AI labs would, you know, voluntarily sign on to follow a kind of standards and certification program where models above any particular size would have to be stress-tested, I guess, in, in all these kinds of different ways to ensure that they're not gonna engage in behaviors that, that we don't like.
Rob WiblinHOST
115:12
I think there, there's a decent amount of buzz around this effort and people, uh, who are helping with include Beth Barnes, who I'm hoping to interview later in the year, and Holden Karnofsky and Paul Christiano, who've been on the show before.
Rob WiblinHOST
115:22
I, I guess we should say that, uh, I think, uh, you and Paul are, are, are an item, so.
Kevin RooseGUEST
29:58
Daniela Amodei, now Anthropic's president.
Kevin RooseGUEST
30:00
Holden Karnofsky, her husband now.
Kevin RooseGUEST
30:03
Um, Chris Olah, Paul Christiano, like all these sort of names from, uh, AI-
Peter KafkaHOST
30:08
All lived in one house
Cory WeinbergCORRESPONDENT
38:06
I don't know.
Cory WeinbergCORRESPONDENT
38:06
I think about it in the orbit of, of like, uh, effective altruism, like sort of people who are interested in like money ball for charity sort of ideas of like, you know, what, what's like the most effective use of this dollar? So, um, uh, Daniela Almada's husband, Holden Karnofsky, was previously, you know, the founder of, of GiveWell, you know, sort of this platform for, you know, ch- channeling donations towards the most effective causes.
Cory WeinbergCORRESPONDENT
38:34
Um, uh, their early...
Cory WeinbergCORRESPONDENT
38:37
You know, Dario and Daniela themselves have been very involved with GiveWell and kind of philanthropic type of organizations for, for a long time.
John HeilemannHOST
40:18
Right.
Nitasha TikuGUEST
40:18
The head of it is married to his sister, Holden Karnofsky.
Nitasha TikuGUEST
40:22
He works at Anthropic.
Nitasha TikuGUEST
40:24
Um, Dario was roommates with him, um, early on in, in his, uh, like, stint in the tech industry.

5 more episodes mention Holden Karnofsky.

Create an account to see the whole feed, search across every transcript, and follow the entities you care about.

We value your privacy

We use cookies to understand how you use our platform and to improve your experience. Click “Accept All” to consent, or “Decline non-essential” to opt out of non-essential cookies. Read our Privacy Policy.