Histamine N-methyltransferase

They have something to do with the MTHFR gene as it relates to you can't look at anything in isolation.

It goes up the sulfation pathway, which we look at the main genes of CBS, BH4, SLUT, which then also intersects with the HRH1, HNMT, HS3T4, the histamine genes.

So when we look up sulfur, we go up the histamine pathway.

And then that we look up with the CYP2D6, with the CYP1A2, with the CYP3A4, with the CYP450 phase one variant of gene.

They are not working as they should.

And like I mentioned earlier, if you have variants in your body that make it harder for you to break down histamine, variants include things like DAO and HNMT that we test for.

If you're not breaking down the histamine, then you can have symptoms like brain fog, puffy eyes, headaches, GI issues, basically anxiety because of the nervous system dysregulation.

There are a lot of symptoms that seem unrelated and are often treated in more of a siloed way when actually they're all connected.

So it's a cool connection.

HNMT is another enzyme.

This degrades histamine in the brain and the liver.

It is dependent on magnesium and methylation.

And oftentimes this can present, issues with HNMT can present as like difficulty falling asleep, difficulty staying asleep, racing thoughts and anxiety as well.

And then a third pathway that is lesser known is sulfation.

And this is just another pathway we can use to clear histamine from the body.

but it's also in the kidney.

And another enzyme, which is fairly a long chemical compound, HNMT stands for histamine N-methyltransferase.

Not that you needed to know that, but this enzyme also breaks down histamine and it's located in your liver, it's in your lungs, and it's even in your central nervous system.

And so if we look at these histamines, the liver and kidney are probably the most important organs the liver receives a tremendous amount of blood flow just like the kidneys in fact one-third of all the blood in your entire body travels through the liver every minute and so anything that inhibits liver function uh can be a problem so this relates to like you know junk foods alcohol or even smoking can actually kind of make things worse so the two central uh good remedies for dealing with histamines would be getting some grass-fed beef kidney extract as well as grass-fed beef liver extract.

If the gut lining is open, histamine is probably going to show up.

Drain number two is called HNMT.

That's the one that clears histamine inside of your cells.

HNMT runs on methylation.

So B vitamins, folate, your whole methylation status, that all decides how well this drain works.

And then after both of those break histamine down, those breakdown products still need to get clear.

But, uh, so in my case, there's another gene that, uh, helps to clear histamine fr- in the liver.

It's, uh, HNMT, and I have a slow version of that one.

Uh, and you- b- basically ever since the mold, my liver has just been...

And then on top of that, I actually have, um, deletion of two of the, uh, uh, three of the GSDM genes.

[laughs] You know?

Right.

I, I had my genetic test, right? So my problem is HNMT, not DAO, so [laughs] I'm not in that category.

[laughs]