HELLP syndrome

The same technique that we used to, to study pregnancy complications, three in particular.

We studied preterm birth, and we studied severe preeclampsia, which is the flavor of preeclampsia that's associated with abnormal and shallow placentation, and we studied a severe variant of preeclampsia called HELLP syndrome-

Yeah

... which has liver platelet involvement.

A- and I, I imagine that is a way to better understand the light switches.

What we might-- You're not gonna go in there and mess with every gene, 'cause there's, it's too many genes.

Can you, can you look at those gene networks to assess what you might, for lack of a better term, mess with to try to reduce the probability of generating either severe preeclampsia or, or HELLP syndrome?

Yes.

Talk about preeclampsia, including the role of the placenta, why it can become so dangerous, and how it's managed.

Talk about HELLP syndrome and other severe complications of pregnancy.

We discuss stillbirth and its potential causes and why so many cases remain unexplained even after extensive testing.

We discuss the trade-offs between C-sections, vaginal delivery, and how clinicians think about the risk and trade-offs of each, and how pregnancy complications can affect a woman's health well beyond pregnancy, including her future risk of metabolic, cardiovascular, and kidney disease.

... because it's become a very interesting recent discussion, which, which we should spend some time on.

LFTs, platelets.

Boy, this sounds a lot like HELLP syndrome.

So can I don't remember what HELLP stands for.

Right.

Specifically, HELLP syndrome and acute fatty liver of pregnancy or AFLP.

Yeah.

The slides mention this.

But we are gonna cover spontaneous abortion or miscarriage, ectopic pregnancy.

Uh, we're gonna talk about placenta previa and placental abruption, hyperemesis gravidarum, and then we're gonna address gestational, um, hypertension and the, the cascading effect that it can have leading to pre-eclampsia, eclampsia, and HELLP syndrome.

So that is going to be the primary focus.

Like I said, there are other disorders that are in that chapter, uh, but for the purposes of this podcast, these are the big ones that we are gonna highlight.