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Glymphatic system

Glymphatic system

Search complete. 77 mentions across 11 episodes found for "Glymphatic system".

Nov 9, 2026

Eric PhelpsGUEST
26:30
And I think we end up, what I talked about last night, we end up with down-regulation of dopamine receptors.
Eric PhelpsGUEST
26:37
And then there's this issue of glymphatic drainage.
Eric PhelpsGUEST
26:43
All right.
Eric PhelpsGUEST
26:43
So again, you learn in the suffering.
Eric PhelpsGUEST
30:53
What's the neurophysiology? What's actually happening? And so I was in between patients one morning and I just saw this kid with ADHD and I said, I got him.
Eric PhelpsGUEST
31:04
So I I looked at Gimeno stuff and then I just got on cloud and I just started questioning things about mechanisms.
Eric PhelpsGUEST
31:17
And it was dopamine downregulation and glymphatic drainage.
Eric PhelpsGUEST
31:23
And then I just knew it.
AlexHOST
5:03
They described a system of fluid channels running alongside the brain's blood vessels using glial cells, which are these sort of supporting cells for the brain, and that was sort of described as the structural framework for the brain.
AlexHOST
5:19
And we call it the glymphatic system combining glial, which is the sort of type of brain cell, with lymphatic, so glymphatic.
AlexHOST
5:28
And what this system does... is absolutely remarkable.
AlexHOST
5:32
So during your sleep, cerebrospinal fluid, so CSF, cerebrospinal fluid, which is that clear liquid surrounding your brain and your spinal cord, and it's what comes out when we do a lumbar puncture, This is actively pumped through these different channels and it's flushing metabolic waste out of your tissue as it does that.

14 MINS LATER

AlexHOST
20:06
We know that alcohol is one of the most reliably documented disruptors of your sleep architecture.
AlexHOST
20:13
How well you sleep.
AlexHOST
20:14
and even just small amounts of alcohol before bed, it reduces the proportion of deep, slow-wave sleep, which is precisely the stage when your glymphatic system sort of is working hardest.
AlexHOST
20:27
The impairment isn't dramatic after a single drink.
Grant RobertsonHOST
24:59
REM
Louise Parr-BrownlieGUEST
25:00
... glymphatic.
Grant RobertsonHOST
25:00
No. [laughs]
Louise Parr-BrownlieGUEST
25:01
No, no, REM sleep.
Grant RobertsonHOST
25:02
Yeah.
Louise Parr-BrownlieGUEST
25:02
But the glymphatic system, where it actually drains, um, toxins and, and bad proteins that you need to clear from your brain.
Grant RobertsonHOST
25:11
Mm.
Louise Parr-BrownlieGUEST
25:11
Um, and it only happens when you're in deep sleep, so, um, you need deep sleep.
Cat de LangeHOST
1:01
This is a really, really important topic that we're going to talk about today.
Cat de LangeHOST
1:06
And it is the glymphatic system.
Cat de LangeHOST
1:08
So not everyone would have heard of that.
Cat de LangeHOST
1:09
Helen, this was your idea.
Cat de LangeHOST
1:11
Tell us what you're thinking.
Helen ThomsonHOST
1:13
Okay, so normally I have heard about this stuff because I've got a neuroscience degree, you know, I write about it all the time, but actually the glymphatic system is fairly new and it always excites me when we suddenly find out something new about the brain.
Helen ThomsonHOST
1:26
I didn't know about this in my degree.
Helen ThomsonHOST
1:29
It appeared like 10 years after I first studied neuroscience.
Jin W. SungHOST
15:42
What I'm trying to teach you here is the process that occurs when you actually do the intermittent fasting and how a profound impact you can have on your body if you can catch it early enough.
Jin W. SungHOST
15:56
if you can catch alzheimer's or parkinson's disease early on and you start implementing a ketogenic diet intermittent fasting you can have a profound effect without any really taking any nutrients or supplements you can have a profound effect just on dietary intake alone how to clean the brain the glymphatic system what is it what are some of the conditions associated with it Most importantly, how do we improve the lymphatic system to improve our overall health? So let's get right into it.
Jin W. SungHOST
16:33
The lymphatic system is analogous to the lymphatic system of our body.
Jin W. SungHOST
16:38
Basically, it's the lymphatic system of our central nervous system, which is brain and spinal cord.
Jin W. SungHOST
18:53
Now, here are some of the important things that you need to do to help enhance the lymphatic system.
Jin W. SungHOST
19:01
Number one really is sleep.
Jin W. SungHOST
19:04
They've done studies on animals, And they noticed that when you have proper amounts of sleep between seven and nine hours of good deep sleep, you will have better clearance of the glymphatic system.
Jin W. SungHOST
19:19
Also sleeping on your right side is the best position to enhance the system or clear the system.
EmilyHOST
23:34
I want to go back to some more of the science.
EmilyHOST
23:38
And when I was doing a little research on your research, I didn't know this term before, the glymphatic system.
EmilyHOST
23:45
But could you talk a little bit about the glymphatic system and sort of what that means and how that operates in the brain? So I think it really relates to what we're talking about here.
Alarik ArenanderGUEST
23:56
If you live in the house, you have to keep things clean.
Alarik ArenanderGUEST
23:58
Because just like things get disorderly and you have to throw things away, if you're in a kitchen, if you don't clean up, it's hard to work in the kitchen.
Alarik ArenanderGUEST
24:53
So basically...
Alarik ArenanderGUEST
24:55
During slow-wave sleep in particular, the first sort of hour of your sleep at night, or 90 minutes if you're really good at it, and then following off during the different dreaming and isolation during the night, the system is pumping out all the garbage.
Alarik ArenanderGUEST
25:08
Glymphatic system is removing all the garbage.
John OssipinskyGUEST
8:10
Well, now we know there's a direct lymph brain connection.
John OssipinskyGUEST
8:14
And even though there's a lot of attention to the glymphatic system, that's a specific system inside your brain.
John OssipinskyGUEST
8:20
And it's really just like a little sheath that just pulls fluid through your brain, clearing cerebrospinal fluid and waste.
John OssipinskyGUEST
8:25
But what's important is that the glymphatic system must flow to the lymphatic system because they found lymphatic vessels right around the meninges, the meningeal lymphatic vessels.
John OssipinskyGUEST
8:36
It's right around the brain.
John OssipinskyGUEST
8:37
So if your lymphatic system in your neck, under your clavicles in your neck is congested, then how can your glymphatic system clear waste into your lymphatic system? And that's the point that we're missing.
John OssipinskyGUEST
8:49
So it's important to understand the glymphatic system, but the glymphatic system must flow to the lymphatic system.
John OssipinskyGUEST
8:56
And that's why the lymphatic system always becomes more important for really everything.
Trevor BachmeyerHOST
39:40
and three is the slow wave deep sleep listen to this one pay attention okay delta waves below 2 hertz with amplitude exceeding 75 micro volts so representing synchronized cortical neuronal down states which the glymphatic system the pressure washer for your brain your brain's lymphatic waste clearance network activates to clear tau protein, amyloid beta, all the accumulations linked to dementia, Alzheimer's disease.
Trevor BachmeyerHOST
40:04
2023, nature aging confirmed.
Trevor BachmeyerHOST
40:06
Glymphatic clearance is exclusively, oh, I got to get this out, exclusively dependent on slow wave activity.
Trevor BachmeyerHOST
40:12
It can't be inferred from any peripheral physiological measurement whatsoever.
Trevor BachmeyerHOST
40:16
how does your watch know again i'll help you it can't rem sleep okay rapid eye movement shows desynchronized low amplitude electron cephalogram eeg pattern paradoxically similar to wakefulness didn't know that did you complete skeletal muscle atonia mediated by glycinergic inhibition of motor neurons rapid conjugate eye movements visible only through electrooculography This is where memory consolidation, this is so important, memory consolidation, emotional processing, synaptic homeostasis occur through mechanisms requiring active neural monitoring to even detect.
AmandaHOST
25:41
The lymphatic
MarkHOST
25:41
system of the brain? Glymphatics, yeah.
Jennifer StrukhoffGUEST
25:43
Yeah, glymphatics, yeah.
Jennifer StrukhoffGUEST
25:45
And he talked about it last year, too.
Trevor BachmeyerHOST
51:32
2023 nature agent confirmed.
Trevor BachmeyerHOST
51:33
Glymphatic clearance is exclusively sleep stage dependent, specifically requiring deep 10 rem slow wave activity to function.
Trevor BachmeyerHOST
51:42
So when your watch incorrectly tells you that you got 47 minutes of deep sleep, when you actually got 90, you believe you have a serious sleep deficit.
Trevor BachmeyerHOST
51:50
And you know what you do? You take melatonin.

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