Glutathione S-transferase

They're not good.

So there's a family of genes called the GST family, glutathione S-transferase.

And these are the enzymes that clear things like estrogen and environmental toxins and all that sort of stuff out of your system.

And I've got the very poor versions of those.

And that's the one that changed my life the most.

So phase one and phase two liver detox, the CYP450 enzymes, CYP1A1, 1A2, 2E1, CYP3A4 and the rest.

The GST family that I mentioned, GSTM1 and the P1 and then there's NAT2 and PON1 and the vitamin D pathway genes.

CYP2R1 and the VDR receptors, lots of gobbledygook.

And one commonly discussed area is the HLA system, which plays an important role in immune recognition.

And here are some genetic variants involving pathways such as GST, CYP enzymes, UGT, EPHX, oxidative stress, and glutathione metabolism.

Now, what do all those acronyms stand for? Well, these are tests that you can have done through Vibrant Wellness Labs, and it's under your toxic genetics test where they examine selected genetic variants related to your ability to detox.

So basically, it's your toxic load metabolism.

So that's phase one activity.

And then in the second, um, step, there's, uh, uh, GST, glutathione S-transferase, and then combining, uh, glutathione to, um, convert it into a natural product that's gotten, gotten rid of.

And so, uh, estrogen has this, uh, property where it gets converted to a semiquinone, uh, first and then into a quinone through oxidation.

And so that, that's that second product that can be a DNA adduct and, and, and a problem.

And, and so if it's already low a little bit, then you're not metabolizing your, your, uh, estrogen as, as quickly as someone else.

And so that estrogen that isn't inactivated as quickly would, would be one of the pathways in which you can become estrogen dominant.

And then the same with if your glute-- your, um, glutathione levels are lower than normal, um, or if you have, uh, GSTM1 or a couple of the other GST enzymes, we don't-- where you don't conjugate the glutathione as, as efficiently.

You can also have, um, uh, in- a decreased ability in metabolizing estrogen, um, correctly, and those would also lead to estrogen-- possible estrogen dominance.