Glutathione S-transferase Mu 1

So phase one and phase two liver detox, the CYP450 enzymes, CYP1A1, 1A2, 2E1, CYP3A4 and the rest.

The GST family that I mentioned, GSTM1 and the P1 and then there's NAT2 and PON1 and the vitamin D pathway genes.

CYP2R1 and the VDR receptors, lots of gobbledygook.

What it means is this determines your world tolerance for things like alcohol, for medications, for mold, for heavy metals, for pesticides, for plastics, and it determines how hard you have to work to stay ahead of your own exposures.

So there's deletions.

The genes are called GSTT1 and GSTM1.

And about half of the population is missing at least one copy of GSTM1.

30% to 40% of the population is missing at least one copy of GSTT1.

So it's not rare at all.

So, um, we're, we're tracking all of that too.

too.Well, if, if I may, I will just ex- expand on some of the things that you've said, that after working with, you know, thousands of mold patients myself, and being one, you know, a lot of these people, myself included, are GSTM1, um, you know, have SNPs, and so they don't have glutathione.

It's another reason that they get into this boat.

And so typically what I'm using is an acetylated glutathione, as well as I have a product that's liver support, which is all the precursors to glutathione, and then the coconut, you know, charcoal binder complete.

It neutralizes and removes toxins, things that cause inflammation and damage to your gut wall and gut barrier.

GSTM1 specifically is active in the gut.

And so whatever toxins come along with your food, for our ancestors, there would have been mold and, you know, parasites and things like that.

GSTM1 is meant to get rid of it and prevent it from getting past the gut into your bloodstream.

That gene is missing for me.

So it's not even about a variant or a mutation or there's a phenomenon called a copy number variation.

And you can look at all that big stuff and your everyday biology can be optimized.

Well said.

And so that estrogen that isn't inactivated as quickly would, would be one of the pathways in which you can become estrogen dominant.

And then the same with if your glute-- your, um, glutathione levels are lower than normal, um, or if you have, uh, GSTM1 or a couple of the other GST enzymes, we don't-- where you don't conjugate the glutathione as, as efficiently.

You can also have, um, uh, in- a decreased ability in metabolizing estrogen, um, correctly, and those would also lead to estrogen-- possible estrogen dominance.

But just in general, if you're, if you're inflamed and oxidized, you're gonna, you're gonna drive your estrogen into the, into that, um, oxidized estrogen pathway, which in general would be, would be detrimental.

Um, there's SNPs in NQO1, the one that, that, um, reverses the, uh, quinone, uh, estrogen quinones.

Um, there's probably other ones, but I think knowing where you are on the spectrum, there's a-- oh yeah, the GSTs.

There's GSTM1.

Uh, so if you're unable to conjugate to glutathione as efficiently, you can also be, um, estrogen, uh, dominant.