GLUT4
ProteinWikipedia
81
MENTIONS
41
EPISODES
35
PODCASTS
Search complete. 81 mentions across 41 episodes found for "GLUT4".
Sep 14, 2026
Anthony ChaffeeGUEST
Um, the RDAs are very different if you're eating plants or animals.
Anthony ChaffeeGUEST
And, uh, vitamin C, for instance, if you're not eating carbohydrates, you only need them measured in nanograms, whereas if you are eating carbohydrates, because they block out, uh, their absorption and utilization through, from the GLUT4 receptor, uh, you need them in milligrams.
Anthony ChaffeeGUEST
You need a million times more vitamin C if you're eating carbohydrates.
Anthony ChaffeeGUEST
So plants can have, absolutely can have positive aspects, but that doesn't mean that they don't come without a cost, and they can be more harmful than good potentially, depending on the plant.
RichieHOST
but most diets cut out junk food
AmberHOST
so true so true and it could also be true that maybe seeing your glucose improve is extremely rewarding because it is true that Your cells need insulin to unlock the door to the cell to let the glucose get inside in absence of that GLUT4 pathway where your muscles can take it in.
AmberHOST
In the absence of insulin, your brain can take glucose in as well.
AmberHOST
But as a whole, you need insulin to unlock the door to your cells and let glucose get in.
Nastasia IronsGUEST
So if you don't have as much, it's floating around going like, where's the house I can enter? You know, like instead of being like, oh, look, all these places, let's go in.
Nastasia IronsGUEST
And then it improves upregulation of something called GLUT4.
Nastasia IronsGUEST
So we...
Nastasia IronsGUEST
We talk a lot about insulin resistance where the body is not opening that door, but we also know that we can add more doors to the cell.
speaker_1HOST
Okay.
speaker_2GUEST
This forces glucose transporters, called GLUT4 molecules, to rise to the surface of the cell and pull glucose in from the blood, completely bypassing the broken insulin signaling pathway.
speaker_1HOST
That is incredible.
speaker_1HOST
So you are draining the glucose without needing the pancreas to shout.
speaker_2SOUNDBITE_SPEAKER
It acts like a key unlocking your muscle cells.
speaker_2SOUNDBITE_SPEAKER
That amplified insulin spike heavily stimulates a mechanism called GLUT4 translocation.
speaker_1SOUNDBITE_SPEAKER
Okay.
speaker_1SOUNDBITE_SPEAKER
I saw GLUT4 heavily referenced in the Gatorade Sports Science Institute papers.
speaker_1SOUNDBITE_SPEAKER
What is the actual mechanism there?
speaker_2SOUNDBITE_SPEAKER
GLUT4 stands for glucose transporter type 4.
speaker_2SOUNDBITE_SPEAKER
If we'd imagine your muscle cell is a fortress, GLUT4 transporters are like tiny drawbridges hidden deep inside the fortress walls.
speaker_1SOUNDBITE_SPEAKER
Okay, drawbridges.
Aaron StrakerHOST
So, the reasons for splitting off the, the non-training days and lowering calories and carbohydrate on the day is holding insulin sensitivity for as long as possible, because that is really the... [swallows] Excuse me, one of the ultimate deciders of, of how long your gain can be and how productive your partitioning ratio can be more favorable when our insulin sensitivity i-i-is better.
Aaron StrakerHOST
Very similar to that is nutrient partitioning, right? We can take advantage of basically times like post-workout where we have, uh, GLUT4 translocation, which is non-glucose mediated...
Aaron StrakerHOST
Sorry, non-insulin mediated glucose uptake, where we can partition things a little r- more, more favorably.
Aaron StrakerHOST
Um, and with that, we can select foods that would be a little bit more appropriate for that, so something like intraworkout carbohydrate, which is, you know, like, a liquid Gatorade, coconut water, or something like that.
Natalie CrawfordGUEST
They all want to do Pilates and run.
Natalie CrawfordGUEST
Nobody wants to lift weights, okay? in your skeletal muscle, so your big muscles on your body, you have a transporter called GLUT4, okay, science.
Natalie CrawfordGUEST
But what GLUT4 does is it's essentially giving glucose the key to the cell and doesn't need insulin.
Natalie CrawfordGUEST
So your skeletal muscle can help bypass this insulin pathway and use up glucose, lowering your glucose levels and helping your cell become more insulin sensitive.
Natalie CrawfordGUEST
So if you want to fight insulin resistance, build muscle.
Arc WomanHOST
If you have time to exercise six days a week, okay, that's where you have a little bit more room to play.
Arc WomanHOST
Pilates and yoga are not forms of resistance training that are also going to stimulate bone mass, all right? So muscle contraction during resistance training, that triggers GLUT4 translocation to the cell membrane and that increases glucose uptake.
Arc WomanHOST
Okay, so what actually is resistance training? So resistance training is pretty much any form of exercise or movement where your muscles contract against an external force to build physical strength, size, and endurance.
Arc WomanHOST
So that could be body weight, using your own weights for movements like push-ups, pull-ups, or squats.
Dave FeldmanHOST
But getting back to the RER, then going to get a respiratory exchange ratio test, I'm running as though I'm burning out fat like crazy, right? Again, get myself into trouble, but I believe the Occam's razor is this is just the Randall cycle.
Dave FeldmanHOST
What's happening is when I'm militantly keto like a lot of these other folks, we have less GLUT4 expression, full stop.
Dave FeldmanHOST
There's just more fatty acids in the cytosol of our cells, therefore there's less expression.
Dave FeldmanHOST
So again, getting back to it doesn't take much.
Ryan LucasGUEST
This is what that looks like in muscle and fat.
Ryan LucasGUEST
Insulin drives the transportation of GLUT4 transporter and glucose is brought into the cell and then it's phosphorylated which keeps it in the cell.
Ryan LucasGUEST
It's a little bit different in the liver.
Ryan LucasGUEST
In the liver glucose uptake is by GLUT2 which is insulin independent but insulin upregulates glucokinase the enzyme that does this phosphorylation and therefore keeps insulin in the cell.
31 more episodes mention GLUT4.
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