GLUT2

But one of the jobs of T3 is to support carbohydrate metabolism, including enzymes involved in glucose handling and glycolysis, such as phosphofructokinase 1 and pyruvate kinase.

It also increases the density of glucose transporters such as GLUT1, GLUT2, and GLUT4.

Now glycolysis is simply the process of breaking down glucose for energy, and this is where the T3 pyruvate connection matters.

When you run more carbohydrate through the system, you create more demand for the machinery involved in glucose metabolism.

And so the recommendation that we're going to provide, this is across the board, not just if you have this gene SNP per se, is to stop eating three hours before bed.

The next gene that is linked to this is the liver glucose transporter gene, and that is SLC2A2 or the GLUT2 gene.

And this is a transporter of glucose into and out of the liver.

And which genotype you have actually shifts how well metformin works by the equivalent of about 550 milligrams of metformin.