Generalized pustular psoriasis

It's just kind of the way we've all kind of had this immediate reaction because they've been so darn effective.

When it comes to plaque psoriasis, can you talk about why maybe that wouldn't be the best approach in this sort of a scenario with GPP? Why do IL-17 and IL-23 inhibitors

fall short? Well, Raja, for perspective, I always like to know what we're up against.

And when we think about that, the simplest way is to crystallize it with numbers.

Coming back to the clinical aspect, because I've taken care of some of these patients, and one of the challenges that I've always had is, gosh, it's easy to think if you don't see it on the skin anymore, it's all gone.

But we know that that's not totally true here, so the disease isn't just gone completely.

Can you talk about what is the chronic auto-inflammatory nature of GPP and why just treating the flares in between isn't the approach that we should be taking?

This is such an important point, Raja.