Do you think we can use muscle fat signature to create a risk profile for the risk of knee replacement, which would allow for an opportunity for early non-surgical intervention?

That's such an exciting question.

And as we think about it, it could be our next project, so, so thanks for that idea.

So whether muscle fat infiltration precedes cartilage degeneration, that's still actively being studied.

But if that relationship does hold, it opens a window for earlier intervention, which would be so exciting and so impactful for the patients.For the second question, could a muscle fat signature become part of a risk profile for knee replacement? Yes, potentially, but we would need prospective validation.

There's a lot of studies that would need to be done, um, standardization, and evidence that it's modifiable and clinically meaningful before it's ready for routine use.

What I can say is that we're already building this type of framework in our lab.

Do you think there's a role for AI to do the segmentation of, uh, muscle and fat?