Fusobacterium

Um, and, you know, you mentioned fusobacterium and, and since a throat culture doesn't know have a gram stain with it because i know like a lot of texts you know when you get other sources right they see it on the gram stain and then they put notes hey you know i think we have fused bacteria so we're kind of looking for it and um but for that one yeah it's just it's it's you know you don't have anaerobic plates and and you're looking at aerobic plates so there's no gram stain so yeah that's one that um you know in our kind of bacterium yeah we don't see it as much and it's kind of cool when you do see it i mean of course from the nerdy micro side you know seeing those very tiny, you know, beta grant positive rod searches.

Well, you know, I've wondered if we're not missing it because we're not holding our plates long enough.

Um, is a it's a cool bug and so my you know maybe we're shooting ourselves in the foot with with our culture practices but i bet you if we held our culture for 72 hours most most labs are going to hold their throat cultures for either 24 maybe 48 hours but i bet you if you held them for 72 hours we'd pick up a lot of arcano bacterium and the few that we've seen they're they're pretty tiny at 24 hours um i i guess you might pick some up that way um but also like another and you and i can maybe patent this right here and we can become millionaires because this is a great idea Um, it may not be, but, um, I would be really interested in some sort of an anaerobic selective media for Fusobacterium macrophorum.

Um, I, I just, it's something that we, we miss a fair amount and probably it doesn't matter.

Probably those all get better on their own anyway, but it's a huge chunk of pharyngitis that this thing causes.

And to my point, like obviously the mouth is riddled with anaerobes, so you'd have to have some sort of a selective media.

Um, But Fusobacterium necrophorum especially, you'd want your media to look for that especially and somehow differentiate from the other Fusobacterium that are normal flora.

I'm of the mind that necrophorum is not.

Et je vais prendre l'exemple du cancer colorectal.

On sait qu'il y a une grande partie des gens qui ont un cancer du colorectal, un cancer colorectal, euh, qui ont dans leur microbiote une bactérie, d'un certain sous-type d'une bactérie qui s'appelle Fusobacterium nucleatum, qui est une bactérie à la base de la bouche, euh, qui peut favoriser le développement du cancer colorectal.

Et donc, ça, pour le coup, c'est une bactérie qui n'est pas considérée comme pathogène puisqu'on sait simplement qu'elle peut favoriser le développement d'une maladie, mais elle n'entraîne pas une infection.

Donc cette bactérie-là, elle n'est pas recherchée à l'heure actuelle chez les donneurs et peut-être qu'on la transfère sans s'en rendre compte à des gens qui souffrent d'une pathologie bénigne, qui, dix, vingt, trente ans plus tard, vont peut-être faire un cancer du côlon ou une autre maladie chronique qu'ils n'auraient pas forcément fait avec leur microbiote initial.

Et donc ça, pour le coup, ça doit conduire à de la prudence parce qu'on ne maîtrise pas ça.

Et là, j'ai pris un exemple avec le Fusobacterium dans le cancer colorical, mais probablement que dans les prochaines années, on va découvrir encore d'autres signatures microbiennes, d'autres consortiums de bactéries qui, euh, une seule n'entraînera pas de souci, mais une avec d'autres pourra potentiellement favoriser le développement de mauvaises, de, de pathologies.

Oui, parce que même si, par exemple, ils ont un manque crucial peut-être de certaines bonnes bactéries qui chez lui ne développent rien, euh, mais chez l'autre peut potentiellement être dangereux.

Donc ça, par exemple, vous identifiez pas, enfin ça fait pas partie du protocole de regarder s'il y a ce Fusobacterium.

They're in the green, but they're not below detection limit.

Some of the autoimmune trigger markers, uh, whether that's Klebsiella or Proteus or Fusobacterium species like this person has, I want it at ze- like I do not want any in the system.

They're very highly associated with developing autoimmune disease.

Um, I don't wanna see any, uh, Candida, and he doesn't have any, and definitely no bacterial pathogens or H. pylori, and again, those things are all clear, which is great.

And with strain level identification, you can start to see more clearly what is happening in the microbiome.

So we identified something, some form of Fusobacteria.

I'm going to say it wrong.

It does have a mouthful of a name.

That's huge.

And 'cause we know there's some very pathogenic oral microbes that can get into the gut, like Fusobacterium, which is linked to colon cancer and, and v- it's very problematic.

You know, again, it's one of the ones that are considered a bad bacteria, that it has d- almost no benefit to-

No

Whereas when they are on a raw food diet, it looks a bit more like kind of a, what in your index you have as a healthy kind of gut index.

So there's going to be differences in the firmicutes in the, Fusobacteria in the bacteroides.

And you're going to also, which is, I mean, it's totally logical if you have very, very little carbohydrates.

There's nothing for those bacteria that like to eat carbohydrates.

But there are more, more and more testing where you can actually take, if there is a pocket in there, so you can actually take a pocket, you can send it off for an oral microbiome swab of that pocket.

So you can put a paper point in the pocket of that tooth and see, is there Fusobacterium in there? Is there something else going on there? You can open up the root canal and flush it out, and then see what is actually in there as well.

You can numb the area up and see does the patient's symptoms change when you, when you, when you make the body realize it's not in there.

But I personally, if the, if I've got no proof that that tooth is, is a problem, I will not take it out.